“Sciatic Nerve Endometriosis: Prevent Muscle Atrophy Caused by Progressive Denervation!

Today, I saw a patient with a rather unusual history. She is over 45 years old and has longstanding symptoms affecting her right leg, with pain distributed in a pattern highly suggestive of involvement of the S1 nerve root.

While taking continuous hormonal therapy, approximately 80% of her symptoms are relieved. Nevertheless, I recommended surgery because MRI revealed marked atrophy of the gluteal, piriformis, and obturator internus muscles, suggesting advanced denervation and chronic nerve damage.

The lesion itself is large, extending toward the sciatic notch and appearing ready to leave the pelvis. In addition, the nodule contains multiple T1 hyperintense foci, consistent with hemorrhagic activity and suggesting that the disease remains biologically active despite the significant symptomatic improvement achieved with medical treatment.

This case raises an important question: should surgery be recommended primarily on the basis of progressive neurological damage and muscle denervation, even when symptoms are largely controlled by hormonal therapy? In this patient, the radiological evidence of ongoing nerve involvement and advanced muscle atrophy weighed heavily in favor of surgical management.”

Proceed to the video attached to the post.

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“Why does the clock read older?

Recent research reveals fascinating insights into our biological age through an epigenetic clock that measures methylation patterns on DNA. As tissues age, these tags shift in a predictable manner, allowing scientists to estimate molecular age by analyzing 353 specific CpG sites. Remarkably, this study found that even in young women, the endometrial pattern resembled that of older tissue!

Dive deeper into this groundbreaking study by Del Aguila et al. published in Fertility and Sterility. Understanding the age of our tissues can pave the way for new approaches in health and fertility!”

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“I was pleased to contribute expert commentary to this article in The Guardian discussing new research on occupational activity and miscarriage risk in early pregnancy.

The study, which analysed more than 800,000 pregnancies, found associations between certain workplace activities, particularly prolonged forward bending, and an increased risk of miscarriage. However, it is important to interpret these findings carefully.

As I highlighted in the article, this is an observational study and cannot establish causation. While the research raises an important hypothesis and contributes valuable data to an area where evidence has been limited, further studies are needed before these findings can be translated into specific workplace recommendations.

For clinicians, employers and policymakers, the key message is that supporting women in early pregnancy should remain a priority, while ensuring that guidance is grounded in robust evidence. For pregnant women, these findings should not be interpreted as meaning that normal daily movement or activity is unsafe.

Advancing maternal health requires both scientific curiosity and careful interpretation of emerging evidence. I welcome research that helps us better understand how workplace environments may influence pregnancy outcomes.

Full article.”

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“Spindle dynamics and chromosome segregation in human preimplantation embryos

Full text.”

Title: Spindle dynamics and chromosome segregation in human preimplantation embryos

Authors: Filip Vasilev, Yanwen Jiang, Gaudeline Rémillard-Labrosse, Jade Latraverse-Arquilla, Jin-Tae Chung, William Buckett, Greg FitzHarris

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“Today is World Sickle Cell Day.

Sickle cell disease is a risk factor for preeclampsia. Sickle cell disease is a group of inherited blood disorders that cause red blood cells to become rigid, sticky, and crescent-shaped. A risk factor doesn’t mean that patients will automatically get preeclampsia; it is a warning sign to watch and evaluate for low-dose aspirin in pregnancy.

Learn more.”

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“Parametrial endometriosis represents one of the most challenging manifestations of deep infiltrating endometriosis

Due to its close anatomical relationship with the autonomic pelvic nervous system, ureter, and major vascular structures, surgical treatment requires a detailed understanding of parametrial anatomy and a nerve-sparing surgical strategy

Despite increasing awareness, parametrial involvement remains underrecognized and inconsistently described in the literature

This webinar aims to clarify the anatomical, phenotypic, and surgical aspects of parametrial endometriosis, highlighting modern approaches that balance radical disease excision with preseryation of pelvic nerve function

Date: 25 June 2026
Time: 7 PM CET

Register now via the link.

Moderators: Nucelio Lemos, Filipa Beja Osório, Ahmet Kale, Diego Raimondo

Speakers: Benoit Rabischong, Taner Usta, Shaheen Khazali, Vito Chiantera.”

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“PMOS can make conception harder. But harder doesn’t mean impossible.

With the right support—lifestyle changes, ovulation-focused care, insulin management, and early intervention—many in our Cysterhood find hope and real progress.

Too many face infertility in silence. Too many carry shame or confusion about their options.

You deserve answers. You deserve support. You deserve compassionate care.

Together, we empower. Together, we thrive.”

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“The future of fertility won’t be shaped by technology alone. It will be shaped by technology built alongside the people who deliver fertility care every day. Over the years, I’ve learned that successful fertility programs aren’t built on clinical expertise alone. They rely on systems that connect patient care, laboratory processes, operations, and the multidisciplinary teams behind every treatment cycle.

Having helped establish and optimize fertility services from the ground up, I’ve seen firsthand where patients struggle, where clinics lose efficiency, and where innovation has the potential to make the greatest impact.

That’s why I’m passionate about contributing beyond the clinic. As fertility and women’s health technology continues to evolve, there is a growing need for clinical voices to be involved early, not simply to validate ideas, but to help shape them from the outset. Whether it’s patient experience, IVF workflows, clinical protocols, or the realities of delivering fertility care at scale, I believe these perspectives can make the difference between a product or business that looks good on paper and one that truly improves outcomes.

I’d love to hear from and collaborate with founders, innovators, and organizations building the next generation of fertility and women’s health solutions.

If you’re out there let’s talk!”

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“Call for Abstracts – Pain, Stress Managment and Menstrual Health Challenges in Young Women | GFWH 2026

Menstrual health remains a significant yet often overlooked aspect of adolescent and young women’s well-being. Irregular periods, menstrual pain, hormonal fluctuations, and societal stigma can contribute to stress, anxiety, emotional distress, and delayed healthcare-seeking behavior among young females. In many communities, fear of judgment, lack of awareness, and communication barriers further impact their physical and mental health.

The 12th Global Summit on Gynecology, Fertility & Women’s Health (GFWH 2026) invites researchers, gynecologists, adolescent health specialists, psychologists, public health professionals, educators, and healthcare practitioners to submit abstracts focused on Pain, Stress Management & Menstrual Health Challenges in Young Women.

Date: November 23-24, 2026
Location: Bangkok, Thailand

Key Focus Areas:

• Irregular menstrual cycles and adolescent health
• Menstrual pain (dysmenorrhea) and quality of life
• Psychological stress associated with menstrual disorders
• Impact of social stigma and communication barriers
• Anxiety and emotional challenges related to menstrual health
• PCOS and hormonal disorders in adolescents
• School, academic, and social impacts of menstrual problems
• Lifestyle, nutrition, and exercise interventions
• Mental health support and counseling approaches
• Education and awareness programs for menstrual well-being

Why Present at GWFH 2026?

• Opportunity for Oral, Poster & Virtual Presentations
• Earn 15 CME Credits supporting professional development
• Present your research to a global audience
• Official Presentation & Participation Certification
• Publication opportunities in reputed journals
• Access keynote lectures, scientific sessions & expert discussions
• Network with international healthcare professionals and researchers
• Foster collaborations in adolescent and women’s health research

Abstract Submission Deadline: June 30, 2026

Submit your abstract.
Download brochure.

Contact.

For Enquiries:
Devyanshi Dixit – Conference Manager
+44 7378558315.”

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“Such a great time this week teaching in the MS program at Eastern Virginia Medical School for the Reproductive Clinical Laboratory Science program. The Students presented their MS project proposals this week, you all did a GREAT job! Thank you to all the vendors that made this week such a terrific experience. I am so impressed by these students that choose to go back to school and learn all they can about this field!”

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