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Rasha Zenasni: Shared Biological Pathways Between Male Infertility and Neurodegeneration
Rasha Zenasni/LinkedIn
Apr 29, 2026, 10:07

Rasha Zenasni: Shared Biological Pathways Between Male Infertility and Neurodegeneration

Rasha Zenasni, Laser Technician at Blooming Center, shared a post on LinkedIn:

“Male infertility and neurodegenerative diseases: what if it all started long before the symptoms?

Recent data from a systematic review (2026) shed particularly interesting light on a concept that is still underestimated: male infertility as an early marker of neurological vulnerability.

What the data shows:

Infertile men show a significant increase in systemic oxidative stress, with levels of sperm DNA damage of up to +20-30% compared to fertile controls.

Mitochondrial alterations are observed in up to 40% of idiopathic infertility cases, with a direct impact on sperm motility.

These same biological signatures (oxidative stress, mitochondrial dysfunction, apoptosis) are consistently found in neurodegenerative diseases.

A key point: the convergence of mechanisms

Neurons and sperm share:

  • a strong mitochondrial energy dependence
  • Extreme sensitivity to oxidative stress
  • vulnerability to protein and DNA alterations

This parallelism suggests a common systemic vulnerability and not two independent pathologies.

Towards a paradigm shift

Traditionally thought of as a local disorder, male infertility may actually reflect: a global biological imbalance a breeding ground for neurodegeneration an early warning signal potentially detectable years before neurological clinical manifestations

Major clinical involvement This opens up new perspectives:

Integrating the assessment of male fertility into a predictive medicine approach

Exploring common brain-gonad biomarkers, rethinking infertility as a window of observation of cellular aging

Male infertility is not only a reproductive issue, but could be a mirror of overall neurological health

A transversal approach, at the interface between neurology and reproduction, is now essential.

Male Infertility and Neurodegenerative Diseases’ (2026, IJMS / PubMed)”

Rasha Zenasni

Stay updated on all scientific advances in the field of fertility with Fertility News.

apoptosis brain-gonad biomarkers cellular aging DNA Fertility Fertility News infertile men male infertility Mitochondrial alterations mitochondrial dysfunction neurodegenerative diseases Neurological Health oxidative stress Rasha Zenasni reproductive health Reproductive Issues Reproductive Medicine
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