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Alberto Sifuentes Giraldo: Innovative CAR–T Cell Therapy Promises SLE Remission and Fertility
Feb 27, 2026, 13:45

Alberto Sifuentes Giraldo: Innovative CAR–T Cell Therapy Promises SLE Remission and Fertility

Alberto Sifuentes Giraldo, Rheumatologist, Medical Doctor at National University of San Marcos, shared a post on LinkedIn:

“BCMA/CD19 dual-target CAR–T cell therapy can induce long-term systemic lupus erythematosus (SLE) remission, preserve fertility, and enable successful, healthy pregnancies/neonatal outcomes, as evidenced by the interesting case of a 24-year-old female patient with refractory class IV lupus nephritis who received this therapy and achieved sustained molecular remission (>30 months) with no flares:

  • She had two spontaneous pregnancies (conceiving at 6 and 21 months post-infusion), resulting in term vaginal deliveries of healthy female infants.
  • No CAR–T cell DNA was detected in maternal blood, breast milk, placenta, or infants’ blood (at birth and follow-up), confirming no vertical transmission.
  • Both infants showed normal growth, neurodevelopment, and immune function during follow-up.

The patient’s quality of life markedly improved post-therapy.

This appears to represent one of the first detailed reports addressing fertility and pregnancy safety in the context of this emerging treatment for SLE, highlighting the need for pregnancy-related guidelines in post-CAR–T autoimmune patients.

Jiang Q, Wang M, Wang M, Zhou J, Zheng K, Ding L, Hong M. Successful spontaneous pregnancies and healthy neonates after dual-target CAR–T cell therapy in systemic lupus erythematosus. Arthritis Rheumatol, 2026.”

Title: Successful Spontaneous Pregnancies and Healthy Neonates After Dual-Target CAR–T Cell Therapy in Systemic Lupus Erythematosus

Authors: Qinglian Jiang, Mingxia Wang, Ming Wang, Jiajun Zhou, Kaijun Zheng, Ling Ding, Ming Hong

Read the full article.

Alberto Sifuentes Giraldo: Innovative CAR–T Cell Therapy Promises SLE Remission and Fertility

Alberto Sifuentes Giraldo Autoimmune Patients Breast Milk CAR–T cell Fertility Fertility News fertility preservation Jiajun Zhou Kaijun Zheng Ling Ding lupus nephritis maternal blood Ming Hong Ming Wang Mingxia Wang placenta pregnancy pregnancy-related guidelines Qinglian Jiang reproductive health Reproductive Medicine SLE Systemic Lupus Erythematosus Vertical Transmission
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