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All the Available Evidence on the Relationship Between Chronic Endometritis and RIF – RBMO
Antonio D'Amat/LinkedIn
Oct 3, 2026, 07:03

All the Available Evidence on the Relationship Between Chronic Endometritis and RIF – RBMO

Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn about a paper by Antonio D’Amato et al.:

“This systematic review by Antonio D’Amato and team across several IVI RMA GLOBAL clinics synthesized all the available evidence on the relationship between chronic endometritis and RIF, with specific attention to:

  • prevalence,
  • diagnostic approaches,
  • therapeutic strategies,
  • their impact on clinical pregnancy and live birth rates.

Three main themes are drawn from the analysis and discussed in this review:

  1. the wide variability in prevalence estimates;
  2. heterogeneous diagnostic criteria, with CD138 IHC as the de facto reference but the diagnostic criteria applied lacking consistency and standardization; and
  3. mixed results in terms of reproductive outcomes after treatment compared with control groups.

The authors make clear recommendations for next steps to advance clinical practice:

  1. establish clear, reproducible diagnostic criteria;
  2. conduct adequately powered prospective, controlled studies that use uniform CE definitions and verify cure; and
  3. assess outcomes under controlled conditions (ideally single euploid blastocyst transfers) so that any treatment effect is not confounded by embryo aneuploidy or endometrial protocol variability.”

Title: Chronic endometritis and recurrent implantation failure: prevalence, diagnostic approaches and therapeutic strategies – a systematic review.

Authors: Antonio D’Amat, Andres Reig, Andrea Etrusco, Vittorio Agrifoglio, Juan Giles, Pietro Molinaro, Antonio Pellicer, Elena Labarta.

You can read the Full Article in Reproductive Biomedicine Online.

Evidence, RBMO

Other articles featuring Reproductive BioMedicine Online on Fertility News.

Andrea Etrusco Andres Reig Antonio D’Amat Antonio Pellicer Chronic Endometritis Elena Labarta Fertility Fertility News Headlines IVI RMA Global Juan Giles OBGYN Pietro Molinaro RBMO Recurrent Implantation Failure Reproductive BioMedicine Online reproductive health Reproductive Medicine RIF Vittorio Agrifoglio Women’s Health
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