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Can Oral Dydrogesterone Improve Outcomes in Natural-Cycle FET? – RBMO
RBMO/LinkedIn
May 29, 2026, 19:06

Can Oral Dydrogesterone Improve Outcomes in Natural-Cycle FET? – RBMO

Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn:

“The findings of this new study from Caroline Roelens and colleagues suggest that the potentially deleterious impact from low serum progesterone on the day of blastocyst transfer in NC-FET cycles may be avoided when oral dydrogesterone is administered. This supports a personalized approach to luteal phase support in true and modified natural cycles.

The authors say:

‘The present results suggest that oral dydrogesterone supplementation may be associated with comparable pregnancy outcomes in true and modified NC-FET and modified NC-FET cycles when serum progesterone concentrations are suboptimal on the day of blastocyst transfer. In contrast, the empirical addition of LPS in patients with adequate progesterone concentrations does not appear to be associated with additional benefit.’

RBMO subscribers can read the full paper from our in-press articles section now.”

Title: Can oral dydrogesterone mitigate adverse outcomes with low progesterone on transfer day in natural-cycle frozen embryo transfer?

Authors: Caroline Roelens, Charlotte Van Overberghe, Fatih Aktoz, Lisbet Van Landuyt, Shari Mackens, Michel De Vos, Herman Tournaye, Christophe Blockeel.

Can Oral Dydrogesterone Improve Outcomes in Natural-Cycle FET? – RBMO

Stay updated on all scientific advances in the field of fertility with Fertility News.

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