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DIVINE Calculator Makes IVF Dosing Safer Without Reducing Effectiveness – RBMO
RBMO/LinkedIn
Apr 9, 2026, 07:40

DIVINE Calculator Makes IVF Dosing Safer Without Reducing Effectiveness – RBMO

Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn:

“The DIVINE dose calculator uses easily obtainable patient characteristics to provide clinicians with multiple possible starting doses, each with estimated safety risks and expected live birth implications

This new study from Nienke Schouten, Theodora van Tilborg, Daniela Cianci, Marinus Eijkemans, Marieke Lambers, and Frank J.M. Broekmans investigates the use of this calculator in routine care, and its influence on reducing treatment risk due to ovarian hyperstimulation.

The authors found that implementing the calculator for FSH dose picking in routine IVF/ICSI care resulted in a more safe and equally effective approach in first, fresh IVF/ICSI cycles.

While standard dosing may result in similar live birth rates, individualised dosing can lead to fewer adverse events due to an excessive ovarian response and will be a valuable part of the preventative management of OHSS for predicted high responders.

While more research is needed to fully evaluate the benefits of implementing the DIVINE dose calculator, the results in this paper indicate its promising potential as a tool for optimisation of fertility care.

The paper is published open access, available to read in full from our in-press articles section, now.”

Title: The DIVINE dose-selection model in daily ART practice: effects on live birth rate and safety

Authors: Nienke Schouten, Theodora van Tilborg, Daniela Cianci, Marinus Eijkemans, Marieke Lambers, and Frank J.M. Broekmans

DIVINE Calculator Makes IVF Dosing Safer Without Reducing Effectiveness – RBMO

Stay updated on all scientific advances in the field of fertility with Fertility News.

Daniela Cianci DIVINE Fertility Fertility News Frank J.M. Broekmans FSH ICSI IVF Live Birth Rates Marieke Lambers Marinus Eijkemans Nienke Schouten RBMO Reproductive BioMedicine Online reproductive health Reproductive Medicine Theodora van Tilborg
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