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Matteo Molè: Collaborative Innovations in Embryo Implantation Research
Matteo Molè/med.stanford.edu
Dec 29, 2025, 13:24

Matteo Molè: Collaborative Innovations in Embryo Implantation Research

Matteo Molè, Assistant Professor of Medicine at Stanford University School of Medicine, shared a post on LinkedIn about papers published in Cell:

“Opening the ‘Black Box’ of Human Implantation.

We are proud to share our latest research, published in Cell: ‘Modeling human embryo implantation in vitro’

For decades, the moment a human embryo attaches to the uterus has remained a ‘black box’ biologically critical but impossible to observe. By creating CREST (Cell-engineered Receptive Endometrial Scaffold Technology), we have successfully achieved human embryo implantation in vitro.

  • The Time is Now: We have moved beyond observing embryos in a dish; we can now study the complex interface between the embryo and the mother.
  • Improving IVF: Implantation failure is the primary barrier to pregnancy. By recapitulating this process, we hope to understand why it fails and significantly increase success rates for patients.
  • Global Collaboration: This was a massive joint effort between The Babraham Institute, IVIRMA Global, and Stanford University.

We are also excited to be part of a landmark trio of papers moving this field forward today. Please see the related work by our colleagues.”

Title: Modeling human embryo implantation in vitro

Authors: Matteo A. Molè, Sarah Elderkin, Irene Zorzan, Christopher Penfold, Nicole Horsley, Alexandra Pokhilko, Max Polanek, Andrea Palomar, Molika Sinha, Yang Wang, Alicia Quiñonero, Charalampos Androulidakis, Richard Acton, Kathryn Balmanno, Anneliese Jarman, Jhanavi Srinivasan, Adam Bendall, Sara Morales-Álvarez, Roberto Yagüe-Serrano, Katie Heywood, Stephen Harbottle, Mina Vasilic, Suzanne Cawood, Srividya Seshadri, Paul Serhal, Lauren Weavers, Ippokratis Sarris, Anastasia Mania, Rachel Gibbons, Lucy Laurier, Immaculada Sánchez-Ribas, Amparo Mercader, Pilar Alamá, Anthony Hoa Bui, Graham J. Burton, Tereza Cindrova-Davies, Ridma C. Fernando, Afshan McCarthy, Lusine Aghajanova, Liesl Nel-Themaat, Ruth B. Lathi, Simon J. Cook, Kathy K. Niakan, Alexander R. Dunn, Francisco Domínguez, Peter J. Rugg-Gunn

Read the full article.

Matteo Molè

Title: 3D post-implantation co-culture of human embryo and endometrium

Authors: Jinzhu Song, Rusong Zhao, Yu Zhang, Minghui Lu, Peishu Liu, Tao Li, Cheng Li, Ruijie Yu, Xueyao Chen, Huajian Yang, Xinwen Zhang, Yining Su, Yanli Han, Duanchen Sun, Qingbin Zhou, Zhenzhen Hou, Weijing Liu, Xiaoyuan Gao, Wenrong Tao, Jingye Zhang, Han Zhao

Read the full article.

Matteo Molè

Title: A 3D in vitro model for studying human implantation and implantation failure

Authors: Qian Li, Yang Yuan, Wentao Zhao, Yuanjun Li, Juanzi Shi, Yu Xiu, Mi Han, Yan Han, Junmei Zhang, Shuhan Cheng, Xin Qi, Xizhuang Sun, Tan Jia, Jiaqi Xing, Siwei Deng, Xiaodi Yan, Seiya Oura, Hongfei Li, Ying Sun, Huiyao Yuan, Xiaohong Ma, Miaomiao Xin, Jianchao Zhao, Xili Zhu, Cong Wang, Qin Wang, Ge Lin, Xiaokui Yang, Yulei Wei, Jun Wu, Hongmei Wang, Leqian Yu

Read the full article.

Matteo Molè

Stay updated on all scientific advances in the field of fertility with Fertility News.

Adam Bendall Afshan McCarthy Alexander R. Dunn Alexandra Pokhilko Alicia Quiñonero Amparo Mercader Anastasia Mania Andrea Palomar Anneliese Jarman Anthony Hoa Bui Assisted Reproductive Technologies Biomedical Innovations Cell Engineering Charalampos Androulidakis Cheng Li Christopher Penfold Cong Wang CREST Technology Developmental Insights Duanchen Sun embryo development Embryonic Studies Endometrial Research Fertility Fertility News fertility research Francisco Domínguez Ge Lin Graham J. Burton Han Zhao Hongfei Li Hongmei Wang Huajian Yang Huiyao Yuan Human Embryo Implantation Immaculada Sánchez-Ribas Implantation Mechanisms In Vitro Models Ippokratis Sarris Irene Zorzan IVIRMA Global Jhanavi Srinivasan Jianchao Zhao Jiaqi Xing Jingye Zhang Jinzhu Song Juanzi Shi Jun Wu Junmei Zhang Kathryn Balmanno Kathy K. Niakan Katie Heywood Lauren Weavers Leqian Yu Liesl Nel-Themaat Lucy Laurier Lusine Aghajanova Matteo Molè Max Polanek Mi Han Miaomiao Xin Mina Vasilic Minghui Lu Molika Sinha Nicole Horsley Paul Serhal Peishu Liu Peter J. Rugg-Gunn Pilar Alamá Qian Li Qin Wang Qingbin Zhou Rachel Gibbons Reproductive Biology Richard Acton Ridma C. Fernando Roberto Yagüe-Serrano Ruijie Yu Rusong Zhao Ruth B. Lathi Sara Morales-Álvarez Sarah Elderkin Seiya Oura Shuhan Cheng Simon J. Cook Siwei Deng Srividya Seshadri Stanford University Stem Cell Applications Stephen Harbottle Suzanne Cawood Tan Jia Tao Li Tereza Cindrova-Davies The Babraham Institute uterine environment Weijing Liu Wenrong Tao Wentao Zhao Xiaodi Yan Xiaohong Ma Xiaokui Yang Xiaoyuan Gao Xili Zhu Xin Qi Xinwen Zhang Xizhuang Sun Xueyao Chen Yan Han Yang Wang Yang Yuan Yanli Han Ying Sun Yining Su Yu Xiu Yu Zhang Yuanjun Li Yulei Wei Zhenzhen Hou
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