Michael Ceulemans։ What About the Safety of DOACs During Pregnancy?
Michael Ceulemans, Senior Postdoctoral Fellow of the Research Foundation Flanders (FWO) at Research Foundation Flanders, shared a post on LinkedIn about a paper he co-authored with colleagues published in the Journal of Thrombosis and Haemostasis.
“What about the safety of DOACs during pregnancy? We now have more evidence thanks to this publication from a recent international research collaboration within ENTIS (European Network of Teratology Information Services).
I am particularly pleased that we were able to contribute Belgian cases and (control) data from the BELpREG pregnancy registry, and grateful for the hard work of all the authors and collaborators involved.
The study can be summarized as follows.
‘First-trimester DOAC exposure was not associated with a substantially increased risk of major birth defects or pregnancy loss, and the observed defects did not suggest a teratogenic pattern, consistent with reported findings in the existing literature. These results offer further reassurance for counselling in case of inadvertent exposure. Larger studies are still warranted to validate these findings due to a limited sample size and window of exposure.’
Several other safety studies are currently underway or in preparation. Let’s continue building on this important work.”
Title: Reproductive safety of direct oral anticoagulants after maternal exposure in early pregnancy: a comparative ENTIS cohort study.
Authors: Kim Dao, Evelin Beck, Veronique Pizzoglio-Billaudaz, Judith Cottin, Svetlana Shechtman, Orna Diav-Citrin, Reem Murad, Maria Moran, Debra Kennedy, Jonathan Luke Richardson, Maja Ratajczak-Enselme, Kuntheavy Ing Lorenzini, Miranda van Tuyl, Petra J. Woestenberg, Georgios Eleftheriou, Mikako Goto, Izumi Fujioka, Laurent Chouchana, Katarina Dathe Maya Berlin, Michael Ceulemans, Lina Camacho-Arteaga, Valentin Rousson, Leonore Diezi, David Baud, Joanna Sichitiu, Stephanie Padberg, Alice Panchaud, Ursula Winterfeld, Maria Hoeltzenbein.
You can read the Full Article in the Journal of Thrombosis and Haemostasis.
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