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Murugan Nandagopal: Lactobacillus Role in Fertility
Murugan Nandagopal/LinkedIn
Jan 7, 2026, 09:54

Murugan Nandagopal: Lactobacillus Role in Fertility

Murugan Nandagopal,  Senior Scientific Officer  at LifeCell International Pvt.Ltd, shared a post on LinkedIn about a paper published in Biomedical and Biotechnology Research Journal:

“Just Published | Clinical Microbiology and Reproductive Medicine

Endometrial Molecular Microbiome Profiling: Empowering Reproductive Outcomes through Enhanced Pathogen and Lactobacillus Diagnostics

Biomedical and Biotechnology Research Journal | Oct–Dec 2025

After years of seeing unexplained infertility, recurrent implantation failure, and recurrent pregnancy loss, this study answers a critical question clinicians often ask:

Are we missing infections by relying only on culture?

What we did

  • 385 endometrial biopsy samples from Indian women with AUB, RIF, RPL, IVF failure
  • Compared conventional culture vs RT-PCR (EMPOWER panel)
  • Targeted 23 reproductive pathogens + 5 key Lactobacillus species

Key findings that matter clinically

  • 59.7% positivity by RT-PCR vs 37% by culture
  • A clear diagnostic gap with routine methods

Most prevalent pathogens:

Ureaplasma parvum – 13.5%

Enterococcus faecalis – 11.7%

Mycoplasma genitalium – 10.4%

  • Polymicrobial infections detected (missed by culture)
  • No MTB or Neisseria gonorrhoeae in this cohort
  • Chronic endometritis increased with age → 100% >45 years

The Lactobacillus insight (often ignored!)

High Lactobacillus abundance (>10⁵ CFU/ml) strongly associated with pathogen-negative endometrium

Confirms the protective role of Lactobacillus in reproductive success

Why this matters

  • CE is subtle, silent, and underdiagnosed
  • Culture alone is not enough
  • Molecular diagnostics must move from ‘optional’ to ‘routine’ in infertility workups

From empirical antibiotics → precision diagnosis → better reproductive outcomes

One of the largest Indian datasets integrating pathogen detection pluse Lactobacillus profiling in endometrial health.

Grateful to my co-authors, clinicians, and laboratory teams who believe that accurate diagnosis is the first step toward successful fertility treatment.

I must thank Dr Satish Patki sir for his constant Technical support and guidance throughout this study!

We are in the verge of groundbreaking data on Lactobacillus role in fertility to be published soon!

Happy to discuss, collaborate, and share insights with Gynecologists | IVF specialists | Reproductive immunologists | Microbiologists

I am grateful to our team Mukin Kumar, Deepa Murugesan, Alok Dadhich, Gayathri, Sourav Jain, Deepak Dixit, Pooja Trivedi, Kanchan Saini.”

Title: Endometrial Molecular Microbiome Profiling: Empowering Reproductive Outcomes through Enhanced Pathogen and Lactobacillus Diagnostics

Authors: Murugan Nandagopal, Mukinkumar Sonai, Deepa Murugesan, Gayathri Venkateswaran, Sujith Sivan Jayachandran

Read the full article.

Murugan Nandagopal

Stay updated on all scientific advances in the field of fertility with Fertility News.

Alok Dadhich Biomedical Research Clinical Microbiology Deepa Murugesan Deepak Dixit Endometrial Microbiome Fertility Fertility News Gayathri Implantation Failure Infection Detection Infertility Research Kanchan Saini Lactobacillus Profiling Molecular Diagnostics Mukin Kumar Murugan Nandagopal Pooja Trivedi pregnancy loss reproductive health Reproductive Outcomes Sourav Jain
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