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Prolonged Oocyte Storage and Fertility Outcomes: New RBMO Review Highlights Evidence Gaps
Amanda Kauffman/LinkedIn
Oct 16, 2026, 17:16

Prolonged Oocyte Storage and Fertility Outcomes: New RBMO Review Highlights Evidence Gaps

Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn about a paper by Amanda Kauffman et al.:

“Oocyte cryopreservation is essential for fertility preservation, yet the impact of prolonged storage on cryosurvival, embryological, and pregnancy outcomes remains unclear.

This study by Amanda Kauffman, Dalia Karol, Claire Jones, Qixuan Li, Ella Huszti, and Jennia Michaeli, provides an important first step in addressing the knowledge gap regarding prolonged oocyte cryostorage.

While age remains a pertinent predictive factor for fertility outcomes, the available case report data summarised in this review do not show obvious harm from prolonged storage.

The authors conclude that small sample size, methodological heterogeneity, and multiple confounders identified necessitate large-scale prospective studies before definitive clinical recommendations can be made regarding the effect of prolonged cryostorage beyond 10 years.”

Title: Effect of prolonged oocyte cryopreservation for >10 years on reproductive outcomes – a systematic review and meta-analysis

Authors: Amanda Kauffman, Dalia Karol, Claire A. Jones, Qixuan Li, Ella Huszti, Jennia Michaeli

You can read the Full Article in RBMO.

RBMO

Other articles featuring Reproductive BioMedicine Online on Fertility News.

Amanda Kauffman Claire A. Jones Claire Jones Dalia Karol Ella Huszti Fertility Fertility News Headlines Jennia Michaeli OBGYN oocyte cryopreservation Qixuan Li reproductive health Reproductive Medicine Women’s Health
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