Sean Lauber: What to Expect After Complete Embryo Arrest During IVF
Sean Lauber, Founder of Remembryo, shared on LinkedIn:
“A new study found that more than two-thirds of patients with complete embryo arrest still developed at least one usable blastocyst in their next IVF cycle, although they had lower usable blastocyst formation rates overall and were more likely to experience complete embryo arrest again.
Embryo arrest generally occurs when an embryo stops developing before reaching the blastocyst stage. However, IVF labs don’t all use the same criteria for what they consider a usable blastocyst.
George et al. (2026) studied nearly 4000 patients who had two IVF cycles within one year to see if complete embryo arrest in the first cycle affected usable blastocyst formation in the next cycle. The study included PGT-A cycles, where only blastocysts that met the laboratory’s biopsy and freezing criteria were counted (at least grade 4CC by day 7).
Patients with complete embryo arrest had lower usable blastocyst formation rates in their next cycle, and were more likely to experience complete embryo arrest again.
However, more than two-thirds of these patients still developed at least one usable blastocyst in their next cycle. Among the usable blastocysts that formed, the chances of being euploid and leading to a live birth after transferring a single euploid embryo were similar.
The researchers also found no evidence that changing the ovarian stimulation protocol or trigger medication improved usable blastocyst formation.
A limitation of this study is that they only counted usable blastocysts (at least grade 4CC by day 7), so the reported blastocyst formation rates excluded some blastocysts that didn’t meet the lab’s biopsy and freezing criteria.
Check out more details on Remembryo.
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