ANA Testing as Routine Diagnostic Work-Up of Women Experiencing REPL – RBMO
Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn about a paper by Valerie Uvin et al. published in RBMO:
“This new study examines the prevalence of antinuclear antibodies (ANAs) in women with recurrent early pregnancy loss (REPL), and whether they affect subsequent pregnancy outcomes.
The data presented by the author team led by Valerie Uvin at Vrije Universiteit Brussel, indicates that there is no higher prevalence of ANA positivity in women experiencing REPL.
The authors say ‘We believe there is currently insufficient evidence to incorporate or withhold ANA testing in the routine diagnostic work-up of women experiencing REPL in the absence of clinical signs of a systemic autoimmune disease. In addition, we were unable to demonstrate any significant impact of ANA positivity on the outcome of a subsequent pregnancy. Taken together, these findings do not support the current common practice of routine ANA testing in women with REPL, nor the use of (immunologic) add-on treatments in the presence of ANA positivity. Rather, they provide reassurance that ANA positivity alone does not justify additional interventions outside a research setting.’
RBMO subscribers can read the full paper from our in-press articles section now․”
Title: Antinuclear antibodies in women with recurrent early pregnancy loss: prevalence and impact on subsequent pregnancy outcome
Authors: Valerie Uvina, Lieve Lernera, Karin Melsensb, Simke Demeesterc, Ronald Buyld, Corinne Evers-lebrunb, Michael De Bruckera, Herman Tournayea, David Unuanef, Shari Mackensa
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