Nibhash Kumar: Can an Intact Acrosome During ICSI Contribute to Fertilization Failure?
Nibhash Kumar, Junior Embryologist and Quality Manager at Indira IVF Group, shared a post on LinkedIn:
“Can an intact acrosome during ICSI contribute to fertilization failure?
Acrosome contains concentrated hydrolytic enzymes. Releasing these enzymes directly inside the oocyte may interfere with normal cellular events and, in some cases, can affect fertilization or early embryo development.
During natural fertilization, the acrosome reaction occurs outside the oocyte before sperm entry. But in ICSI, the sperm is injected directly into the ooplasm, bypassing this physiological process.
This is one reason why sperm tail crush immobilization is considered an important step during ICSI.
By immobilizing the sperm:
- The sperm membrane gets disrupted
- Oocyte activating factors can be released more effectively
- The sperm becomes non-motile
- The risk associated with an intact acrosome may be reduced
Studies suggest that retention of the sperm plasma membrane and acrosome may delay oocyte activation and negatively affect embryo development. Mechanical sperm immobilization helps disrupt the membrane, facilitates release of oocyte activating factors like PLCζ, and may improve fertilization outcomes.”
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Sep 18, 2026, 20:27Hrishikesh Pai: Rethinking Male Infertility
-
Sep 18, 2026, 20:25Eric Verdin: Wrapping Up the Reproductive Aging Summit at the Center for Healthy Aging in Women
-
Sep 18, 2026, 20:21Investigating Pregnancy Outcomes in Women with Idiopathic POI – RBMO
-
Sep 18, 2026, 20:18Sue Ritchie: Why Aren’t We Talking About Male Fertility More?
-
Sep 18, 2026, 20:13Salma Yasin: Every Day of BFS Study Week 2026 Has Been an Exceptional Learning Experience
-
Sep 18, 2026, 20:01Qingcai Wang: Over 35 and Torn Between Trying Longer and Starting IVF?
-
Sep 18, 2026, 19:58Bhumika: Can a Woman Become Pregnant Again While Already Pregnant?
-
Sep 18, 2026, 19:5215 More Experts Join the International Fertility Forum Mumbai 2026
-
Sep 18, 2026, 19:50Curious About What Happens Behind the Scenes in the Labs? – Sims IVF