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Mauro Cozzolino: Comparing HA-Based Sperm Selection with Conventional ICSI in PGT-A Cycles
Mauro Cozzolino/ivi-fertility.com
Aug 29, 2026, 16:38

Mauro Cozzolino: Comparing HA-Based Sperm Selection with Conventional ICSI in PGT-A Cycles

Mauro Cozzolino, Director of IVI RMA Global, shared a post on LinkedIn about a paper he co-authored with colleagues published in Reproductive Biology.

”Our recently published prospective sibling-oocyte randomized study compared HA-based sperm selection with conventional ICSI in PGT-A cycles.

Among 258 embryos analyzed, euploidy rates were comparable between HA-ICSI and conventional ICSI (52.1% vs 54.7%), with no significant association between sperm selection method and embryo euploidy.

These findings suggest that, in patients predominantly characterized by altered sperm DNA fragmentation, HA-based sperm selection does not provide a measurable advantage in embryo chromosomal competence. Whether selected populations with higher DNA fragmentation or severe male-factor infertility may benefit remains an important question for future studies.”

Title: Hyaluronic acid–based sperm selection and embryo euploidy in human PGT-A cycles: A sibling-oocyte randomized study

Authors: Livia Pellegrini, Giovanni Pizzi, Laura Mossetti, Vincenzo Sorrentino, Magda Messina, Lucia Maresca, Mauro Cozzolino

You can read the Full Article in Reproductive Biology.

Mauro Cozzolino: Comparing HA-Based Sperm Selection with Conventional ICSI in PGT-A Cycles

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Fertility Fertility News Giovanni Pizzi Laura Mossetti Livia Pellegrini Lucia Maresca Magda Messina Mauro Cozzolino OBGYN reproductive health Reproductive Medicine Vincenzo Sorrentino Women’s Health
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