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Jordan Abdi: Evaluating Outcomes in Transferring Aneuploid Embryos
Jordan Abdi/LinkedIn
Sep 9, 2026, 09:23

Jordan Abdi: Evaluating Outcomes in Transferring Aneuploid Embryos

Jordan Abdi, Co-Founder and CEO of U-Ploid Biotechnologies, shared a post on LinkedIn about a paper by Manuel Viotti et al. published in Fertility and Sterility:

“Fascinating paper just accepted in Fertility and Sterility evaluating outcomes in transferring aneuploid embryos.

Of the 168 transfers of embryos classified as whole-chromosome aneuploid, there were no live births.

The central drivers of these aneuploidies are segregation errors in the oocyte, especially in patients of advanced reproductive age.

The mean age at retrieval in this study was 40.5, which means that while the conclusion is that 168 embryo transfers failed, they reflect eggs that had already failed.

These are chromosomal segregation errors that carried forward through fertilisation, culture, biopsy, freeze and transfer, and only then counted at the end.

By contrast, segmental errors, which do not track in prevalence with age, behaved very differently, with a live birth rate of 17.1%.

PGT-A has never been better at identifying which embryos will not work; however, it cannot change how many will.

Incredibly important work that underpins the need for interventions to improve egg quality in women of advanced reproductive age.”

Title: Multicenter Assessment of Outcomes After Intended or Non-selective Transfer of Whole Chromosome and Segmental Aneuploid Embryos

Authors: Manuel Viotti, Svetlana Madjunkova, Andria Besser, Francesca Spinella, IRMET Consortium, Sharyn Stock-Myer, Hayden Homer, Iulian Roman, Pavel Yakovlev, Nikolay Kornilov, Christine Wechsberg, Mariana A. Jimenez, Amber R. Cooper, Murat Cetinkaya, Semra Kahraman, Mary Carney, Caroline McCrae, Sergio Vaccari, Peter C. Klatsky, Nam D. Tran, Andrea R. Victor, Frank L. Barnes, Caroline McCaffrey, James Grifo, Clifford Librach, Christo G. Zouves, Mitko Madjunkov

You can read the Full Article in Fertility and Sterility.

Jordan Abdi: Evaluating Outcomes in Transferring Aneuploid Embryos

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Advanced Reproductive Age Amber R. Cooper Andrea R. Victor Andria Besser Aneuploid Embryos Caroline McCaffrey Caroline McCrae Christine Wechsberg Christo G. Zouves Chromosome Segregation Clifford Librach egg quality embryo transfer Fertility Fertility and Sterility Fertility News Francesca Spinella Frank L. Barnes Hayden Homer IRMET Consortium Iulian Roman James Grifo Jordan Abdi live birth Manuel Viotti Mariana A. Jimenez Mary Carney Mitko Madjunkov Murat Cetinkaya Nam D. Tran Nikolay Kornilov OBGYN Oocyte Aneuploidy Pavel Yakovlev Peter C. Klatsky PGT-A reproductive health Reproductive Medicine Segmental Aneuploidy Semra Kahraman Sergio Vaccari Sharyn Stock-Myer Svetlana Madjunkova Whole Chromosome Aneuploidy Women’s Health
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