Karthik Raj: The POSEIDON Concept – Moving Beyond “Poor Responder”
Karthik Raj, Clinical Embryologist at The Boon IVF and Fertility, shared on LinkedIn:
“The POSEIDON Concept: Moving Beyond ‘Poor Responder’
‘Poor responder’ is often too broad a label to explain what is actually happening during ovarian stimulation.
The POSEIDON classification reframes low ovarian response by integrating:
- Age,
- Ovarian reserve,
- Previous oocyte yield,
- Oocyte/ embryo expectations.
Rather than simply asking ‘How many oocytes did we retrieve?’, POSEIDON asks a more clinically useful question:
‘How far are we from achieving the number of oocytes needed for a reasonable chance of success?’
This introduces the concept of the Low Prognosis Patient – where ovarian response, reproductive age and treatment history interact to influence cumulative reproductive potential.
The goal is therefore not merely to label a patient as a ‘poor responder.’
It is to identify the underlying limitation, individualise stimulation and optimise the probability of obtaining enough competent oocytes and embryos.
From response classification – to patient – specific reproductive strategy.”
Other articles featuring Karthik Raj on Fertility News.
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Oct 10, 2026, 16:11Abieyuwa Ehigiamusoe: Starting Your Embryology Journey?
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Oct 10, 2026, 16:10Hajar Vahabzadeh: Embryo Quality – The Science Behind the Laboratory Environment
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Oct 10, 2026, 16:05Marking 15 Years of Fakih IVF Fertility Center
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Oct 10, 2026, 16:04Eleni Polychronidou: How Men Feel About Infertility
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Oct 10, 2026, 16:01Philippos Edimiris: Comparing Programmed Ovulatory FET with Modified Natural Cycle FET
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Oct 10, 2026, 15:53Marga Esbert Algam: A Constructive and Engaging Visit to the Reproductive Medicine Laboratory and Cryobank
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Oct 10, 2026, 15:50Why Mental Health Matters on the Fertility Journey – Egg Donor and Surrogate Solutions
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Oct 10, 2026, 15:46Guy Stroud: Mental Health Matters Just as Much as Physical Health