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Prarthana Mukhopadhyay: What Do We Do Differently Because DFI Is High?
Prarthana Mukhopadhyay/LinkedIn
Oct 11, 2026, 12:44

Prarthana Mukhopadhyay: What Do We Do Differently Because DFI Is High?

Prarthana Mukhopadhyay, Junior Embryologist at Srishti Infertility Clinic, shared on LinkedIn:

“Andrology Troubleshooting #4

High DFI. Now what?

We find sperm DNA fragmentation.

The number is high.

But what can we actually do with that information?

  • Can we treat the cause?
  • Can we improve the sample?
  • Should we change the ART strategy?
  • And what does a high DFI actually mean for a couple who has already experienced recurrent pregnancy loss?

There are options that may be considered:

  • addressing male-factor causes,
  • lifestyle/antioxidant approaches,
  • shorter abstinence,
  • varicocele treatment,
  • or in selected cases, alternative sperm sources for ICSI.

But here’s the uncomfortable part: A high DFI doesn’t automatically tell us which intervention will work.

So perhaps the real challenge isn’t: ‘Is the DFI high?’

It’s: ‘What do we do differently because it’s high?’

Where do you think DFI actually changes clinical decision-making?”

Prarthana Mukhopadhyay

Stay updated on all scientific advances in the field of fertility with Fertility News.

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