Evaluating Hysteroscopic Subendometrial Human Umbilical Cord Blood Platelet-Rich Plasma Injection – RBMO
Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn about a paper by Paula Alonso-Frías et al.:
“This paper presents the first-in-human, multicentre pilot study evaluating hysteroscopic subendometrial human umbilical cord blood platelet-rich plasma (hUC-PRP) injection in women with:
- refractory Asherman’s syndrome (AS),
- endometrial atrophy (EA)
- or thin endometrium (TE).
By integrating extensive proteomic and metabolomic characterisation of hUC-PRP with clinical, vascular and transcriptomic endometrial analyses, this study offers a novel regenerative approach for female patients with infertility-related endometrial disorders, which suffer from a lack of gold-standard treatments.
The author team, led by Paula Alonso-Frías, demonstrates that hUC-PRP administration is associated with improvements in endometrial thickness, endometrial pattern, and neoangiogenesis.
Transcriptomic changes consistent with enhanced proliferation, angiogenesis, hormone responsiveness, and ECM-remodelling suggest activation of a reparative endometrial environment.
The consistent, growth factor-rich composition of hUC-PRP, together with its effects across different endometrial pathologies, supports its biological relevance and provides a rationale for further investigation as a potential regenerative approach in endometrial disorders.”
Title: First multicentre clinical results of human umbilical cord blood platelet-rich plasma for endometrial restoration.
Authors: Paula Alonso-Frías, Adolfo Rodríguez-Eguren, Clara Bueno-Fernandez, María Gómez-Álvarez, Marcos Agustina-Hernández, Emilio Francés-Herrero, Mónica Romeu, Carmen Vidal, Lucía de Miguel-Gómez, Amparo Faus, Ana Monzó, Amparo Carrasco, Antonio Parraga-Leo, Patricia Díaz-Gimeno, Leonor Senent, Carmen Lloret-Sos, María Dolores Gómez-Ruiz, Pedro Asensi Cantó, Pilar Solves, Inés Gómez-Seguí, Begoña Laiz-Marro, Antonio Pellicer, Irene Cervelló.
You can read the Full Article in Reproductive BioMedicine Online.
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