Sean Lauber: Older Male Age Was Linked to Higher Miscarriage Rates With Donor Eggs
Sean Lauber, Founder of Remembryo, shared a post on LinkedIn about a paper by Juan J. Fraire-Zamora et al. published in Human Reproduction:
“As women get older, egg quality becomes a major factor in IVF success. But does the age of the male partner matter too, even when younger donor eggs are used?
In a new study, Fraire-Zamora et al. (2026) examined 1,606 egg donation cycles across seven IVF centers. Embryos were created using partner sperm, and a single blastocyst was transferred.
They found that couples with men over 45 had:
- Higher miscarriage rates (25.4% vs. 15.6%)
- Lower live birth rates (34.3% vs. 42.4%)
These differences remained statistically significant after adjusting for several factors, including egg donor age, recipient age, and embryo grading.
There was no difference in the number of fertilized eggs and blastocysts obtained, so these factors might not be influenced by advanced male age.
However, this was a retrospective study, and the researchers didn’t have information on whether embryos were euploid, which could help explain the results.
This post is a quick look at one study, rather than a full breakdown on Remembryo.
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Title: Advanced paternal age affects miscarriages and live birth outcomes in oocyte donation cycles
Authors: Juan J Fraire-Zamora, Maria Cristina Guglielmo, Elena Bartoli, Marzia Valerio, Serena Maruccia, Mario Romano Mignini Renzini, Elena De Ponti, Maria José Zamora, Rafael Lafuente, Juan José Guillen, Amelia Rodriguez-Aranda, Mariabeatrice Dal Canto
You can read the Full Article in Human Reproduction.
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