RBMO Study Uses AI to Assess Shortened Embryo Warming Protocols
Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn about a paper by Laura Conversa Martínez et al.:
“This study used AI-based image analysis and multiple quantitative endpoints to systematically compare a newly developed shortened warming protocol with conventional warming, with and without fatty acid (FA) supplementation.
The shortened protocol was associated with altered contraction dynamics, increased PI-positive cells, decreased mitochondrial membrane potential, and reduced outgrowth area in vitro.
Although FA supplementation did not affect survival or outgrowth, it supported recovery of lipid droplet content and mitochondrial activity during warming in our model.
In addition, AI-derived EA and LWV scores reflected necrosis-associated impairment and subsequent outgrowth but did not correlate with lipid droplets or mitochondrial activity.
Authors Laura Conversa Martínez, Kenji Ezoe, Tetsuya Miki, Nanoha F. Fujiwara, Tomoko Kuroda, Ana Cobo, Marcos Meseguer Escrivá, and Keiichi Kato say that, provided that: the shortened protocol does not compromise good-quality embryos, it may still be useful for optimizing workflow in patients with many frozen embryos, but ultimately, each clinic should determine which approach best suits its procedures before adopting new technologies.
The full paper is available as a pre-proof to RBMO subscribers from our in-press articles section now.”
Title: Evaluation of artificial intelligence-based blastocysts: effect on viability and metabolic function of shortened warming protocol and fatty acid supplementation.
Authors: Laura Conversa, Kenji Ezoeb, Tetsuya Mikib, Nanoha Fujiwarab, Tomoko Kurodab, Ana Coboa, Marcos Meseguera, Keiichi Kato.
You can read the Full Article in Reproductive BioMedicine Online.
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