Gut Microbiota’s Role in Maternal-Fetal Immune Tolerance – Weill Cornell Medicine
Weill Cornell Medicine shared a post in LinkedIn about a paper by Julia Brown et al. published in Cell:
“Beneficial gut bacteria may help prevent immune system reactions that can lead to pregnancy loss by training a mother’s immune system to adapt to the developing fetus, according to a new preclinical study.
The findings from Weill Cornell Medicine’s Dr. Melody Zeng and Dr. Julia Brown demonstrated that metabolites produced by gut microbes promote the recruitment of two types of protective immune cells to the placenta and help the mother’s immune system learn to tolerate the fetus.
‘During pregnancy, it’s very important that the mom’s immune system is trained to recognize that the fetus is not harmful,’ said Dr. Zeng, who also collaborated with Weill Cornell’s Dr. Virginia Pascual and Dr. Gregory Sonnenberg. ‘That prevents the maternal immune system from attacking the fetus, which can lead to recurrent miscarriages or still births.’
Full story.”
Melody Zeng, Associate Professor of Immunology in Pediatrics at Weill Cornell Medicine, shared Weill Cornell Medicine’s post, adding:
“Thanks Weill Cornell Medicine for highlighting our latest work – out now in Cell Press !
We show that –
- Gut microbiota promotes maternal-fetal tolerance via tryptophan-derived indoles to prime MDSCs & RORγt+ Tregs to suppress IFN-γ/IL-17
- Low placental indoles linked to human recurrent miscarriage
Free access (until 2/5/2026)”
Title: Gut microbiota promotes immune tolerance at the maternal-fetal interface
Authors: Julia A. Brown, Mohammed Amir, Shui Yu, Daniel S.H. Wong, Jinghua Gu, Uthra Balaji, Christopher N. Parkhurst, Seunghee Hong, Lucy R. Hart, Hannah C. Carrow, Mamadou A. Bah, Aparna Ananthanarayanan, Katherine Z. Sanidad, Mengze Lyu, Anisa Siddikova, Marina Lima Silva Santos, Inna Serganova, Gretchen E. Diehl, Josef Anrather, Naohiro Inohara, Melody Y. Zeng
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Aug 15, 2026, 18:00Lamia Sayegh: An Euploid Embryo Is Not the Whole Story…
-
Aug 15, 2026, 17:47Andreas Schallmoser: Age-Dependent Differences in the Utilisation of Ovarian Tissue Cryopreservation
-
Aug 15, 2026, 17:15New Study Examines the Link Between Obesity and Early Pregnancy Loss After Euploid FET
-
Aug 15, 2026, 16:43Mauro Cozzolino: Recipient Age and Reproductive Outcomes in Donor Oocyte Cycles
-
Aug 15, 2026, 16:33Palak Dewaan: Could the Bacteria in Semen Affect Your Chances of Having a Baby?
-
Aug 15, 2026, 14:51Diana Kayal: 1 of 9 Myths about IVF I Correct Most Often in My Clinic
-
Aug 15, 2026, 14:36Connie Stark: The Fertility Industry Solved the Invoice – It Never Solved the Exit…
-
Aug 15, 2026, 13:27Precious Chukwuemeka: IVF Improves the Chances of Pregnancy, but It Doesn’t Guarantee a Baby
-
Aug 15, 2026, 13:15Pratik Raj: Surgical Sperm Retrieval Techniques Used In Azoospermia And Severe Male-Factor Infertility