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Ashok Yadav: Chronic Chorioamnionitis with Eosinophils
Ashok Yadav/LinkedIn
Feb 17, 2026, 13:07

Ashok Yadav: Chronic Chorioamnionitis with Eosinophils

Ashok Yadav, Biology faculty at Apex Academy, shared a post on LinkedIn:

“Chronic Chorioamnionitis with Eosinophils (CCe):-

What Is It?

  • Chronic inflammation of the fetal membranes (chorion + amnion)
  • Key feature: Eosinophil infiltration (not typical in standard chorioamnionitis)
  • Considered an allergic/immune-mediated pattern rather than infectious

Key Characteristics

Feature Description
Timing Chronic process (weeks), not acute infection
Cell type Eosinophils + lymphocytes, plasma cells
Location Chorionic plate, amnion, chorion laeve
Absence Neutrophils (unlike acute chorioamnionitis)

Allergic Pattern Explained

  • Eosinophils = hallmark of Type 2 immune response
  • Suggests fetal allergic sensitization in utero

Possible triggers:

  • Maternal allergens crossing placenta
  • Fetal immune response to environmental antigens
  • Autoimmune/alloimmune mechanisms

Clinical Associations

  • Recurrent pregnancy loss
  • Preterm birth
  • Fetal growth restriction
  • Possible link to childhood allergies/asthma (emerging research)

Diagnosis

  • Histopathology (placental examination)
  • Look for: eosinophilic infiltrates in membranes, often with mast cells

Bottom Line

Not an infection—it’s a chronic allergic-type inflammation of the placenta involving eosinophils, suggesting aberrant fetal immune activation.”

Ashok Yadav: Chronic Chorioamnionitis with Eosinophils

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