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Early Pregnancy Depression Linked to Severe Maternal Morbidity – AJOG MFM
AJOG MFM/LinkedIn
Feb 25, 2026, 17:01

Early Pregnancy Depression Linked to Severe Maternal Morbidity – AJOG MFM

American Journal of Obstetrics and Gynecology MFM – AJOG MFM shared a post on LinkedIn:

“Can early pregnancy depression predict severe maternal morbidity?

In a secondary analysis of the nuMoM2b cohort—a large, prospective, geographically diverse U.S. study of nulliparous patients—researchers found that severe depressive symptoms in the first trimester (EPDS ≥13) were associated with a significantly higher risk of severe maternal morbidity (SMM) without transfusion at delivery.

Notably, this association persisted even after adjusting for sociodemographic factors, psychiatric diagnoses, and psychotropic medication use.

These findings highlight early pregnancy mental health as a potentially important—and modifiable—factor in addressing the maternal morbidity and mortality crisis in the U.S.

Read the full-text.”

Title: Early pregnancy depressive symptoms and severe maternal morbidity

Authors: T. Caroline Bank, Janet Catov, Jiqiang Wu, Lynn M. Yee, Michelle L. Miller, Rebecca McNeil, Lara S. Lemon, Uma M. Reddy, Robert M. Silver, Kelly Zafman, George Saade, Judith Chung, Courtney D. Lynch, William A. Grobman, Kartik K. Venkatesh

AJOG MFM

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