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Arnab Guha: New Insights into miRNA Therapies for Endometriosis and Depression
Arnab Guha/LinkedIn
Nov 15, 2025, 12:24

Arnab Guha: New Insights into miRNA Therapies for Endometriosis and Depression

Arnab Guha, Founder, Director and Chief Visionary Officer at Impeccable Innovations Pvt. Ltd., shared a post on LinkedIn:

“Endometriosis induces depression in mouse models via miRNA dysregulation, leading to hippocampal shrinkage and reduced neurogenesis.

Targeting specific miRNAs – such as inhibitors for miR-125b and miR-451a, or a let-7b mimic – lowers depressive behaviors in tail suspension tests and restores hippocampal area, alongside upregulated genes like GAD45B, JUNB, ARC, and PROX1.

The findings build on prior research linking miRNAs like let-7b to endometriosis treatment in mice, suggesting potential miRNA-based therapies for alleviating psychological symptoms in affected patients.”

Arnab Guha

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ARC Arnab Guha Cancer Research Cancer treatment Clinical Trials depression Depressive Behaviors endometriosis Fertility Fertility News GAD45B Hippocampal Area Hippocampal Shrinkage immunotherapy JUNB let-7b Mimic miR-125b miR-451a miRNA Dysregulation miRNA-Based Therapies Neurogenesis Oncology PROX1 Psychological Symptoms Tumor Biology
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