Sadashiva Pai: Breakthroughs in Ovarian Microenvironment for Infertility
Sadashiva Pai, Founder and CEO at Science Mission LLC, shared a post on LinkedIn:
“Activating dormant eggs to restore fertility
A research team has made a major breakthrough in treating premature ovarian insufficiency (POI). The team discovered that finerenone, a drug used to treat type 2 diabetes-related chronic kidney disease, can promote the development of follicles into mature eggs and form viable embryos in patients with POI. In contrast to traditional strategies focusing solely on direct follicle stimulation, this pioneering study is the first to focus on improving the ovarian microenvironment to treat infertility caused by POI.
A related clinical trial confirmed that the participants experienced significant improvement in follicle development. About half of the participants successfully produced mature eggs, several of which developed into viable embryos. The results confirmed that this ground-breaking approach can restore fertility for women affected by POI. The research findings were published in the prestigious scientific journal Science.
The research team adopted the ‘drug repurposing’ strategy to explore novel treatment for POI-related infertility using drugs that have been approved and backed by established clinical safety data.
the team established a systematic screening platform and selected finerenone, a non-steroidal antifibrotic drug from a library of over a thousand drugs approved by the US Food and Drug Administration (FDA). The team found that finerenone has potential clinical value in improving the ovarian microenvironment and facilitating the development of small dormant follicles.”
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