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Brigitte Leeners: New Insights on Endometrial Lesions and Infertility
Brigitte Leeners/LinkedIn
Dec 2, 2025, 12:00

Brigitte Leeners: New Insights on Endometrial Lesions and Infertility

Brigitte Leeners, Head of the Department of Reproductive Endocrinology at University Hospital Zurich, shared a post on LinkedIn about a paper published in Cells:

“Here, we investigated endometrial stromal cells (ESCs) from different types of endometrial lesions (endometrioma, superficial, and deep endometrial lesions), which revealed distinct differences in proliferation, migration, and contractility among different lesion types and when compared to ESC from normal (eutopic) endometrium. In particular, ESCs from endometriotic lesions showed reduced proliferation but increased migratory capacity, an effect most pronounced in endometrioma ESCs but also evident in ESCs from superficial and deep lesions.

New research from our group at University Hospital Zurich on endometriosis, infertility and CRISPR.”

Title: Endometrial Stromal Cells from Endometriosis Patients Reflect Lesion-Type-Specific Heterogeneity

Authors: Daniel Rodriguez Gutierrez, Marianne R. Spalinger, Alina Astourian, Olivera Evrova, Lucie Berclaz, Monique Hartmann, Ioannis Dedes, Patrick Imesch, Julian M. Metzler, Isabelle Witzel, Mohaned Shilaih, Valentina Vongrad, Brigitte Leeners

Read the full article.

Brigitte Leeners

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Brigitte Leeners Cell Biology CRISPR Endometrial Lesions Endometrial Stromal Cells Endometrioma endometriosis Eutopic Endometrium Fertility News fertility research infertility Reproductive Endocrinology University Hospital Zurich
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