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Key Discoveries in Embryo Implantation Mechanisms Unveiled – ICMR NIRRCH
Nov 23, 2025, 03:15

Key Discoveries in Embryo Implantation Mechanisms Unveiled – ICMR NIRRCH

ICMR – National Institute for Research in Reproductive and Child Health (NIRRCH) shared a post on LinkedIn about a paper by Nancy Ashary et al. published in Nature:

“Implantation of the embryo in to the mother’s uterus is key to initiate pregnancy and IVF success.
Our scientists determined the mechanism of this process. They discovered that two genes (HOXA1O and TWIST2) work in oposition to control the process called as EMT in the uterus at the site where the embryo attaches. Inhibiting EMT leads to implantation and pregnancy failure.

This study was published in the international journal Cell Death Discovery
It was a collaboration with IISc Banglore and and BHU Varanasi.

Read full text here.”

Title: HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation

Authors: Nancy Ashary, Sanjana Suresh, Anshul Bhide, Sharmishtha Shyamal, Pranya N, Saee Patil, Anuradha Mishra, Anuradha A, Shruti R. Hansda, Harshavardhan BV, Mohit Kumar Jolly, Deepak Modi

Key Discoveries in Embryo Implantation Mechanisms Unveiled – ICMR NIRRCH

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Anshul Bhide Anuradha A Anuradha Mishra Deepak Modi embryo Embryology Harshavardhan BV Headlines ICMR implantation IVF Mohit Kumar Jolly Nancy Ashary National Institute for Research in Reproductive and Child Health Nature NIRRCH Pranya N reproductive health Reproductive Medicine Saee Patil Sanjana Suresh Sharmishtha Shyamal Shruti R. Hansda
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