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Marco Zaccaria: Uterine Flexion Angle and the Risk of Adenomyosis
Marco Zaccaria/LinkedIn
May 4, 2026, 18:02

Marco Zaccaria: Uterine Flexion Angle and the Risk of Adenomyosis

Marco Zaccaria, Global Product Manager at ESGE European Society Gynecology Endoscopy, shared a post on LinkedIn about a paper by Anjeza Xholli et al. published in Journal of Clinical Medicine:

“The uterine flexion angle – that is, the angle between the body of the uterus and the cervix – is a clinical factor closely associated with the prevalence and severity of adenomyosis symptoms

Recent studies indicate that a marked angle, particularly when the uterus is retroflexed (angle > 210°), can significantly increase the risk of developing this condition

What is the relationship between adenomyosis and the angle of uterine flexion

1. A flexion angle greater than 210° is associated with a prevalence of adenomyosis that is approximately six times higher than that observed with smaller angles

2. A marked curvature can obstruct menstrual flow, increasing intrauterine pressure during contractions: this elevated pressure may promote the infiltration of endometrial tissue into the myometrium, facilitating the development of adenomyosis

3. Extreme angles (both very narrow <150° and very wide >210°) are associated with more severe menstrual pain as like dysmenorrhea

Here is a 2022 study that explores this topic in greater depth:

Angle of Uterine Flexion and Adenomyosis – PubMed“

Title: Angle of Uterine Flexion and Adenomyosis

Authors: Anjeza Xholli, Umberto Scovazzi, Ambrogio Pietro Londero, Giulio Evangelisti, Elena Cavalli, Maria Giulia Schiaffino, Ilaria Vacca, Francesca Oppedisano, Mattia Francesco Ferraro, Giorgio Sirito, Filippo Molinari, Angelo Cagnacci

Marco Zaccaria

Stay updated on all scientific advances in the field of fertility with Fertility News.

adenomyosis adenomyosis symptoms Ambrogio Pietro Londero Angelo Cagnacci Anjeza Xholli cervix Dysmenorrhea Elena Cavalli Endometrial Tissue Fertility Fertility News Filippo Molinari Francesca Oppedisano Giorgio Sirito Giulio Evangelisti Ilaria Vacca intrauterine pressure Marco Zaccaria Maria Giulia Schiaffino Mattia Francesco Ferraro menstrual flow myometrium reproductive health Reproductive Medicine Umberto Scovazzi uterine flexion angle Uterus
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