Predicting Male-Factor Miscarriage Risk Using dsDNA Fragmentation Analysis – Reproductive BioMedicine Online
Reproductive BioMedicine Online shared a post on LinkedIn about a paper by Andrew Drakeley et al. published in RBMO:
“This new research article from Andrew Drakeley and colleagues presents an approach for predicting male-factor miscarriage risk by utilising the Extend neutral comet assay.
Now able to differentiate between ssSDF and dsSDF, these findings suggest that the inclusion of dsDNA fragmentation analysis in the diagnostic workup of couples experiencing recurrent miscarriage is warranted.
A complete male history, physical examination, and appropriate investigative work-up should be a prerequisite undertaking for a couple presenting with a history of recurrent miscarriage. Whilst lifestyle advice and antioxidant therapy may be sufficient for some, other men require more extensive investigation and individualised treatment. A normal standard semen analysis does not exclude underlying SDF.
The paper is published open access, available to read in full, from our in-press articles section, now.”
Title: Double-stranded sperm DNA fragmentation assessed using comet assay is associated with recurrent pregnancy loss
Authors: Andrew Drakeley, Rebecca L Lunt, Emily Newton, Rachel C Gregoire, Linda Watkins, Katerina Bambang, Ann-Maria Ellard, Craig Ledgerwood, Lewis Rae, Alastair Sloan, Martin Lawlor, Lynsey Poots, Luca Moore, Elizabeth Bailie, Jordi Ribas-Maynou, Tara Moore
-
Jun 19, 2026, 15:54Horace Roman: Sciatic Nerve Endometriosis – Prevent Muscle Atrophy Caused by Progressive Denervation
-
Jun 19, 2026, 15:36Why Does the Clock Read Older? – Fertility Plus
-
Jun 19, 2026, 15:28Asma Khalil: Study Raises Questions About Workplace Activities and Early Pregnancy Outcomes
-
Jun 19, 2026, 15:21Spindle Dynamics and Chromosome Segregation In Human Preimplantation Embryos – Fertility and Sterility
-
Jun 19, 2026, 15:12Today is World Sickle Cell Day – Preeclampsia Foundation
-
Jun 19, 2026, 14:59Marco Zaccaria: ESGE Webinar to Spotlight Advances in the Surgical Management of Parametrial Endometriosis
-
Jun 19, 2026, 14:46PMOS Does Not Make Conception Impossible – PCOS Awareness Association
-
Jun 19, 2026, 14:40Diana Kayal: Successful Fertility Programs Aren’t Built On Clinical Expertise Alone
-
Jun 19, 2026, 14:29Devyanshi Dixit: Call for Abstracts at GFWH 2026