Predicting Male-Factor Miscarriage Risk Using dsDNA Fragmentation Analysis – Reproductive BioMedicine Online
Reproductive BioMedicine Online shared a post on LinkedIn about a paper by Andrew Drakeley et al. published in RBMO:
“This new research article from Andrew Drakeley and colleagues presents an approach for predicting male-factor miscarriage risk by utilising the Extend neutral comet assay.
Now able to differentiate between ssSDF and dsSDF, these findings suggest that the inclusion of dsDNA fragmentation analysis in the diagnostic workup of couples experiencing recurrent miscarriage is warranted.
A complete male history, physical examination, and appropriate investigative work-up should be a prerequisite undertaking for a couple presenting with a history of recurrent miscarriage. Whilst lifestyle advice and antioxidant therapy may be sufficient for some, other men require more extensive investigation and individualised treatment. A normal standard semen analysis does not exclude underlying SDF.
The paper is published open access, available to read in full, from our in-press articles section, now.”
Title: Double-stranded sperm DNA fragmentation assessed using comet assay is associated with recurrent pregnancy loss
Authors: Andrew Drakeley, Rebecca L Lunt, Emily Newton, Rachel C Gregoire, Linda Watkins, Katerina Bambang, Ann-Maria Ellard, Craig Ledgerwood, Lewis Rae, Alastair Sloan, Martin Lawlor, Lynsey Poots, Luca Moore, Elizabeth Bailie, Jordi Ribas-Maynou, Tara Moore
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