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Sean Lauber: Second Transfer Success Often Remains Strong After a First Loss
Sean Lauber/LinkedIn
May 3, 2026, 02:16

Sean Lauber: Second Transfer Success Often Remains Strong After a First Loss

Sean Lauber, Healthcare newsletter writer at SmartBrief, shared a post on LinkedIn:

“After an unsuccessful first transfer or pregnancy loss, it’s common to worry that something is wrong and will happen again.

In a study by Barrett and colleagues, outcomes in the second euploid transfer were very similar, no matter what happened in the first:

  • Live birth rates stayed consistent (~54–59%)
  • The chance of a ‘no pregnancy’ result was similar (~21–23%)
  • Miscarriage rates didn’t increase

In other words, whether the first transfer resulted in:

  • no pregnancy
  • a biochemical loss
  • or a clinical miscarriage
    it didn’t affect the chances of success in the next transfer.

This was for euploids, but they also found similar results for untested embryos.

This suggests that a single unsuccessful first transfer or early loss doesn’t necessarily signal an underlying issue that will repeat.

Important: This study looked at first to second transfers only, and included patients around age 35, so it doesn’t apply to all situations (like recurrent implantation failure or recurrent pregnancy loss).

Check out the details on Remembryo:

Like this post? Get a free weekly summary of the latest IVF research.”

Sean Lauber: Second Transfer Success Often Remains Strong After a First Loss

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biochemical loss Fertility Fertility News first transfer IVF Research Live Birth Rates Miscarriage Rates pregnancy loss recurrent implantation reproductive health Reproductive Medicine Sean Lauber
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