Marco Zaccaria: Pathophysiological Mechanisms of Endometriosis and Adenomyosis
Marco Zaccaria, Global Product Manager at H.S. Hospital Service SpA, shared a post on LinkedIn about a paper by Gerhard Leyendecker et al. published in Archives of Gynecology and Obstetric:
“What pathophysiological mechanism underlies the development of endometriosis and adenomyosis?
The basal endometrium plays a fundamental role, performing essential functions as an endocrine gland and triggering hyperestrogenism in the archimetrium.
In adenomyosis hyperperistalsis might result in myometrial dehiscencies that are infiltrated by basal endometrium with the secondary development of muscolar tissue.
Adenomyotic foci are usually localized in the posterior wall: early lesions present close to fundo-cornual-raphe of the archimyometrium ( change in the shape of the uterus which has a slight indentation or ‘arch’ at the top).
With their muscular component, the adenomyotic lesions might contribute to the increased intrauterine pressure.
The lesions are able to produce estrogen and may therefore be able to sustain their benign proliferative potential: that is why infiltrative endometriosis and adenomyosis may constitute progressive diseases, in rare cases even beyond the menopause.
Below is a link to a study on the pathogenesis and pathophysiology of this benign and debilitating condition.”
Title: Archimetrosis: the evolution of a disease and its extant presentation – Pathogenesis and pathophysiology of archimetrosis (uterine adenomyosis and endometriosis)
Authors: Gerhard Leyendecker, Ludwig Wildt, Matthias W. Laschke, Gerhard Mall
Read the full article.
-
Sep 18, 2026, 20:27Hrishikesh Pai: Rethinking Male Infertility
-
Sep 18, 2026, 20:25Eric Verdin: Wrapping Up the Reproductive Aging Summit at the Center for Healthy Aging in Women
-
Sep 18, 2026, 20:21Investigating Pregnancy Outcomes in Women with Idiopathic POI – RBMO
-
Sep 18, 2026, 20:18Sue Ritchie: Why Aren’t We Talking About Male Fertility More?
-
Sep 18, 2026, 20:13Salma Yasin: Every Day of BFS Study Week 2026 Has Been an Exceptional Learning Experience
-
Sep 18, 2026, 20:01Qingcai Wang: Over 35 and Torn Between Trying Longer and Starting IVF?
-
Sep 18, 2026, 19:58Bhumika: Can a Woman Become Pregnant Again While Already Pregnant?
-
Sep 18, 2026, 19:5215 More Experts Join the International Fertility Forum Mumbai 2026
-
Sep 18, 2026, 19:50Curious About What Happens Behind the Scenes in the Labs? – Sims IVF