Erum Anwar Khan: NICE NG126 2026 Update on Anti-D in Early Pregnancy
Erum Anwar Khan, National Maternity Improvement Advisor at NHS England, shared a post on LinkedIn:
“NICE NG126 Update (2026): Ectopic pregnancy and miscarriage: diagnosis and initial management.
One of the most significant updates in the latest NICE NG126 guideline is the change to Anti-D immunoglobulin use in RhD-negative patients.
Anti-D is no longer recommended before 12 weeks’ gestation (up to 11+6 weeks) for:
- Ectopic pregnancy
- Miscarriage
- Threatened miscarriage
At 12+0 to 12+6 weeks, Anti-D (minimum 250 IU) should be offered for medical or surgical management of miscarriage or ectopic pregnancy, and considered for threatened miscarriage with heavy or recurrent bleeding.
Where there is discrepancy between length of gestation as measured from ultrasound and that calculated from last menstrual period, the findings from ultrasound should be used to guide management.
Kleihauer testing is not recommended for quantifying feto-maternal haemorrhage in this setting. This is not a new update.
This represents a notable shift away from historical practice, where Anti-D was frequently administered following early pregnancy loss regardless of gestation.
The update reflects the growing evidence that the risk of RhD sensitisation before 12 weeks is extremely low and that routine prophylaxis in this group offers limited benefit.
For EPAUs, emergency gynaecology services and primary care, this change will likely reduce unnecessary administration of a blood-derived product, simplify care pathways and support more evidence-based use of Anti-D.”
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Jun 26, 2026, 17:46New Lancet Studies Question the Evidence Behind Common IVF Add-Ons – The Lancet Group
-
Jun 26, 2026, 15:48Heghine Khachatryan: NETosis and Thrombosis in Gynecologic Malignancies
-
Jun 26, 2026, 15:38Amos Grünebaum: Clinical AI Competence Is Becoming a Patient Safety Imperative
-
Jun 26, 2026, 15:37Developing the Next Generation of Gynecologic Oncology Leaders – Society of Gynecologic Oncology
-
Jun 26, 2026, 15:32Ultrasound Features of Ovarian Mature Cystic Teratomas with Malignancy – ISUOG
-
Jun 26, 2026, 15:24Applying PAS Surgical Principles to Complex Caesarean Delivery – GEFOG Health Foundation
-
Jun 26, 2026, 15:21Investigating the Role of Coroners in Perinatal Deaths – PLRG
-
Jun 26, 2026, 15:17Upcoming FIGO Webinar on WHO Contraceptive Guidelines – FIGO
-
Jun 26, 2026, 15:15Khalil Faaed: The Silent Relationship Between the Meiotic Spindle and Zona Pellucida