Sean Lauber/LinkedIn
Nov 9, 2026, 15:49
Sean Lauber: Do Zymot or Other Microfluidic Devices Improve IVF Success?
Sean Lauber, Founder of Remembryo, shared on LinkedIn:
“Zymot can select sperm with less DNA damage, but it’s not clear if it improves live birth rates or embryo quality.
Zymot belongs to a group of devices called microfluidic sperm selection devices. They select sperm with lower sperm DNA fragmentation (SDF).
I’ve put together a new Evidence Guide that brings together all the evidence on Zymot and related devices.
Does it improve pregnancy or live birth?
- Two 2025 meta-analyses reported mixed results: one found no significant benefit; the other found benefits in some analyses.
- Trials generally didn’t transfer all embryos from a retrieval, so it’s not clear if there’s an improvement after a full cycle.
What about fertilization and embryos?
- Some studies report better fertilization or embryo development, but results aren’t consistent.
- Most studies don’t show an improvement in the chance of a euploid.
Who might benefit?
- Some studies suggest that patients with high SDF or male factor infertility may benefit; however, most studies are in general IVF patients.
Any downsides?
- In some cases, there may be a very low recovery of sperm, so having a frozen backup sample may be a good idea.
- Safety studies are limited.
Check out the Evidence Guide and more details on Remembryo.
Like this post? Get a free weekly summary of the latest IVF research.”
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