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Programmed-Cycle Frozen Embryo Transfer as a Risk Factor for PAS – RBMO
RBMO/LinkedIn
Mar 18, 2026, 13:27

Programmed-Cycle Frozen Embryo Transfer as a Risk Factor for PAS – RBMO

Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn:

“While previous studies have investigated the risk of placenta accreta spectrum (PAS) following either Programmed- or Natural-Cycle Frozen Embryo Transfer (PC-FET/NC-FET), this new paper from Tomoyuki Fujita and team in Japan, is the first to compare the risk of PAS between Programmed, Natural, and Stimulated-cycles, with fresh embryo transfer.

The findings indicated that, among all the FET groups, only PC-FET was associated with a significantly higher risk of PAS compared with fresh embryo transfer.

The authors suggest that the incidence of PAS is not attributable to FET techniques per se, but rather to the endometrial preparation protocols applied, and reproductive physicians should recognize that PC-FET is a risk factor for PAS when planning embryo transfer.

RBMO subscribers can read the full paper from our in-press articles section now.”

Title: Risk of placenta accreta spectrum in fresh versus natural, stimulated and programmed cycle frozen-thawed embryo transfer

Authors: Tomoyuki Fujita, Toshiyuki Yoshizato, Kenta Murotani, Hitoshi Obara, Naotake Tsuda

Programmed-Cycle Frozen Embryo Transfer as a Risk Factor for PAS – RBMO

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(PC-FET/NC-FET) embryo transfer endometrial preparation Fertility Fertility News Hitoshi Obara Kenta Murotani Naotake Tsuda PAS placenta accreta spectrum (PAS) RBMO Reproductive BioMedicine Online reproductive health Reproductive Medicine reproductive physicians Stimulated-cycle Tomoyuki Fujita Toshiyuki Yoshizato
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