Alejandro González: Positive Test 4 Days After Blastocyst Transfer?
Alejandro González, Gynecologist at INEBIR (Institute for the Study of Human Reproductive Biology), shared on LinkedIn:
“Positive test 4 days after transferring a blastocyst?
In frozen blastocyst transfers, the urine test detected only 6 of 39 pregnancies (15.4%) on day 4. On day 9, all 39 pregnancies were already detected, although there were two unconfirmed urinary positives in blood.
A positive on day 4 can be real.
Such an early negative does not rule out pregnancy: 33 confirmed pregnancies were still negative.
Early positives were associated with more progressive pregnancies, without proving cause-and-effect.
The results cannot be extrapolated directly to D3 embryos or to fresh transfers, where residual hCG from the trigger can lead to false positives. In addition, a test with a sensitivity of 25 mIU/ml was used and the sample was small.
Key message: Pregnancy can be detected as early as day four, but to get a reliable result you have to wait for the right time for hCG-β.”
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