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Marcos Kulmann: IVM Is Moving to Another Level – What Will It Take to Get There?
Nov 12, 2026, 17:27

Marcos Kulmann: IVM Is Moving to Another Level – What Will It Take to Get There?

Marcos Kulmann, Scientific Director at Nilo Frantz Medicina Reprodutiva, shared on LinkedIn:

“IVM has been discussed in reproductive medicine for years.

But the recent agreement for Ferring to acquire Gameto signals something important: the conversation is moving beyond whether in vitro maturation can work.

The next question is whether it can become more reproducible, scalable and broadly applicable.

Gameto has been developing Fertilo, an IVM platform that uses stem cell derived ovarian support cells to help immature oocytes mature outside the body.

Ferring’s proposed acquisition brings that technology closer to the infrastructure, regulatory experience and global reach of an established reproductive medicine company.

That does not mean the scientific questions are solved.

IVM already has a place in reproductive medicine, particularly for selected patients.

But broader adoption still depends on challenges we have been discussing for years:

  • protocol standardization,
  • reproducibility across laboratories,
  • patient selection,
  • clinical outcomes,
  • long term follow-up.

And this is where I think the Ferring and Gameto agreement becomes particularly interesting.

For a technology to move from promising results in experienced centers to wider clinical use, good science is only one part of the equation.

It also needs development, validation, regulatory pathways, scalable laboratory processes and evidence that the results can be reproduced beyond the teams that created the technology.

This may be the next chapter for IVM.

Not proving that maturation outside the body is possible, but developing the science and infrastructure required for the technology to reach another level.

For those working in reproductive medicine, what do you think will be the biggest challenge for IVM from here?”

Robert Gilchrist, Director of Research, Discipline of Women’s Health at UNSW, shared this post, adding:

“Some interesting discussion points in this post about where IVM is heading in light of significant recent commercial developments in the sector.”

Marcos Kulmann: IVM Is Moving to Another Level – What Will It Take to Get There?

Stay informed with the latest updates in fertility and reproductive medicine on Fertility News.