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Basheer Saeed: How the Immune System Influences Pregnancy Success and Risk
Apr 4, 2026, 05:52

Basheer Saeed: How the Immune System Influences Pregnancy Success and Risk

Basheer Saeed, Lab Specialist at Naif Medical Complex, shared a post on LinkedIn:

“How the immunoglobulins of female is affect or prevent pregnant?

The antibodies (immunoglobulins) in a female affect pregnancy in dual ways; while some are essential for protecting the fetus and stabilizing pregnancy, others can prevent pregnancy or cause serious complications if the immune system attacks the body’s cells or the fetus.

  1. How do antibodies help in successful pregnancy?
    •  Provide passive immunity to the fetus: IgG is the only type that crosses the placenta from mother to fetus, protecting the newborn against infections in the first months.
    • Create immune tolerance: In normal pregnancy, the mother’s immune system modifies its response to accept the fetus (which contains foreign genes from the father).
    • Regulate inflammation: Some antibodies reduce harmful inflammation in the uterus, supporting embryo implantation and placental growth.
  2. How do antibodies prevent or harm pregnancy?
    • Problems occur when the female produces antibodies that attack reproductive cells or the fetus, known as immune infertility:
    • Anti-sperm antibodies (ASA): May be produced in cervical mucus, attacking sperm and preventing fertilization.
    • Antiphospholipid syndrome (APS): Causes clots in placental vessels, leading to implantation failure or recurrent miscarriage.
    • Rh incompatibility: If the mother is Rh-negative and the fetus is Rh-positive, she may produce antibodies attacking the fetus’s red blood cells.
    • Attacking egg or embryo cells: The immune system may mistakenly target embryos, preventing pregnancy.
  3. Using immunoglobulin as treatment:
    • Intravenous immunoglobulin (IVIG) is used to:
    • Modify immune balance and reduce natural killer cell activity that may attack the fetus.
    • Increase live birth rates in women with cellular immune disorders.”

Basheer Saeed

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antibodies Basheer Saeed cellular immune disorders embryo implantation female Fertility Fertility News fetus IgG Immune Tolerance immunoglobulin Intravenous immunoglobulin IVIG Natural Killer Cells passive immunity placental growth pregnancy pregnant reproductive health Reproductive Medicine Uterus
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