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Adrenal Involvement in Antiphospholipid Syndrome – ARP Rheumatology
Jan 11, 2026, 09:56

Adrenal Involvement in Antiphospholipid Syndrome – ARP Rheumatology

ARP Rheumatology shared a post on LinkedIn:

“Adrenal involvement in antiphospholipid syndrome (APS) is rare but potentially fatal.

This case-based review highlights that APS-related adrenal failure may present atypically, leading to diagnostic delay – particularly in men. Awareness of this manifestation is essential, as early diagnosis and prompt initiation of anticoagulation and hormonal replacement significantly improve outcomes.

Key message: APS should be considered in patients with new-onset primary adrenal insufficiency, and adrenal involvement should be systematically evaluated in APS patients with compatible symptoms”

Title: Adrenal failure as an antiphospholipid syndrome manifestation: case-based review

Authors: Mariana Emília Santos, Catarina Gama, Bernardo Marques, Tiago Saldanha, Joana Tremoceiro, Maria Helena Lourenço, Maria João Gonçalves, Manuela Costa, Alexandre Sepriano

Read the full article.

ARP Rheumatology

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