Fertility News/LinkedIn
Dec 1, 2025, 01:47
Christine Allen: Real-Time Insights on Early Embryo Development
Christine Allen, Scientific Board Advisor at Alife, shared a post on LinkedIn:
“Impressively well designed article.
What the study did:
- The authors used live-imaging and computational analysis to observe early human embryos (pre-implantation) in real time — something that historically was mostly studied on fixed (stained) embryos.
- They focused on how and when morphological defects (those associated with poor development or failed implantation) arise at the level of individual cells.
— What this means for embryo development and IVF
- The study provides direct, real-time evidence that many morphological “defects” seen in early human embryos (and associated with poor development or failed implantation) arise from concrete, identifiable errors in mitosis and cytokinesis — not random noise or artefacts alone.
- These mitotic and cytokinetic abnormalities are likely a major root cause of developmental failure in human embryos used in IVF or research.
- Therefore, observing and understanding cell-level division behaviors — rather than just final embryo morphology — may be critical to assess embryo viability more accurately. This could have important implications for embryo selection in IVF, research on embryo development, and understanding early human developmental failure.
- Lastly, the findings argue for the value of live-imaging and dynamic monitoring (instead of only static snapshots) to reveal hidden cell-division errors that predispose embryos to fail, which could improve both scientific understanding and clinical practice.”
Title: Capturing aberrant cell behaviors producing defects in human embryos via live imaging
Authors: Hiroki Akizawa, Ana Domingo-Muelas, Maria Pardo-Figuerez, Blake Hernandez, Goli Ardestani, Robin M. Skory, Marta Venturas, Piotr Tetlak, Stephanie Bissiere, Denny Sakkas, Carlos Simon, Nicolas Plachta
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