Cristiana Sieiro Santos: EULAR 2025 Recommendations for Systemic Lupus Erythematosus with Kidney Involvement
Cristiana Sieiro Santos, Postdoctoral Research Fellow at The University of Manchester, shared a post on LinkedIn about a paper by Antonis Fanouriakis et al. published in Annals of the Rheumatic Diseases:
“EULAR 2025 Recommendations for Systemic Lupus Erythematosus (SLE) with Kidney Involvement
A major update published in Annals of the Rheumatic Diseases (Fanouriakis et al., 2025) provides evidence-based and consensus-driven guidance for managing lupus nephritis, reflecting recent advances and new therapeutic options.
Key highlights
- Diagnosis and monitoring – Kidney biopsy remains essential. Aim for preserved/improved kidney function at 3 months, and proteinuria <700 mg/g at 12 months.
- Combination therapy – Early use of glucocorticoids (rapid taper), mycophenolate or low-dose IV cyclophosphamide combined with biologics (belimumab, obinutuzumab) or calcineurin inhibitors (voclosporin, tacrolimus).
- Steroid minimisation– ≤5 mg/day by 4–6 months, with the goal of withdrawal once sustained response is achieved.
- Non-immune management– Incorporates RAAS blockade, SGLT2 inhibitors, cardiovascular and bone protection, and up-to-date vaccination strategies.
- Multidisciplinary care– Shared rheumatology–nephrology management and informed decision-making are central to improving long-term outcomes.
Pregnancy should be planned only after ≥6 months of inactive nephritis, with compatible medications and close multidisciplinary supervision.
Kidney replacement therapies, including pre-emptive transplantation, are recommended once extrarenal disease is controlled.”
Title: EULAR recommendations for the management of systemic lupus erythematosus with kidney involvement: 2025 update
Authors: Antonis Fanouriakis, Myrto Kostopoulou, Hans-Joachim Anders, Jeanette Andersen, Martin Aringer, Michael W. Beresford, Andrea Doria, Eleni Frangou, Richard Furie, Dafna D. Gladman, Frederic Houssiau, Alexandre Karras, Marios Kouloumas, Anastasia-Vasiliki Madenidou, Ana Malvar, Smaragdi Marinaki, Chi Chiu Mok, Gabriella Moroni, Ioannis Parodis, Simona Rednic, Cristiana Sieiro Santos, Carlo Alberto Scire, Josef S. Smolen, Farah Tamirou, Yoshiya Tanaka, Y. K. Onno Teng, Elisabet Welin, George Bertsias, Dimitrios T. Boumpas
Read the full article.
-
Oct 11, 2025, 06:44The Global IVF Market Is Set to Reach $65B by 2032 – Meddilink
-
Feb 27, 2026, 13:45Alberto Sifuentes Giraldo: Innovative CAR–T Cell Therapy Promises SLE Remission and Fertility
-
Feb 27, 2026, 13:27Ovarian Reserve’s Impact on Miscarriage Risk – RBMO
-
Feb 27, 2026, 13:12ACOG’s Outstanding Editorial Team for Menopause – ACOG
-
Feb 27, 2026, 11:26Phase-Dependent Cytokine Dynamics of Endometrium – Fertility and Sterility
-
Feb 27, 2026, 08:51Pregnancy with Lupus Is No Longer a Distant Possibility – The Lupus Foundation of Australia
-
Feb 27, 2026, 08:43Celebrate Your Triumphs: Share Your Joyful Milestones – ASRM
-
Feb 27, 2026, 08:30Exploring Maternal Mental Health and Neonatal Risks in SSRI Study – AJOG MFM
-
Feb 27, 2026, 08:25Trust in Data, Trust in Science: Webinar on Research Integrity and Patient Safety – ESHRE
-
Feb 27, 2026, 08:13Have You Registered for Our Next Journal Webinar Yet? – RBMO