Ferran Barrachina: Treg Cell Depletion Triggers Autoimmunity and Male Infertility
Ferran Barrachina, Director of Analytical and Therapeutic Development at Gameto, shared a post on LinkedIn about a paper he and his colleagues co-authored published in Nature:
“Excited to share that a new article from my former postdoctoral research at Harvard Medical School and Massachusetts General Hospital has been published in Nature Communications!
In this study, we demonstrate how the depletion of Treg cells disrupts immune tolerance in male reproductive organs. This breakdown leads to chronic autoimmunity, the production of anti-sperm antibodies, impaired sperm function, and the formation of tertiary lymphoid structures, ultimately contributing to reduced fertility.
This work highlights key mechanisms underlying male infertility and opens new avenues for precision-targeted therapies and even contraceptive strategies.
Congratulations to the entire team, and especially to Maia Lina Elizagaray and Maria Agustina Battistone, for their outstanding contributions!
Link to the article.”
Title: Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders in mice
Authors: Maia L. Elizagaray, Ferran Barrachina, Maria C. Avenatti, Isinsu Bastepe, Angela Chen, Ainize Odriozola, Oluchi Ukairo, Vanina G. Da Ros, Kiera Ottino, Nerea Subiran and Maria A. Battistone
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Nov 2, 2026, 17:08Elena Milner: The 2nd Class of the School of Embryology Is Already in Full Swing
-
Nov 2, 2026, 17:05November Is National Diabetes Month – PCOS Awareness Association
-
Nov 2, 2026, 17:04Thanos Papathanasiou: Are We Preparing Patients for the IVF Cycle, or for the IVF Journey?
-
Nov 2, 2026, 17:02Anna Morales: Why Is It So Hard to Build in Women’s Health?
-
Nov 2, 2026, 16:59Rickard Ericsson: Honored to Take on the Role of Interim CEO of the Vitrolife Group
-
Nov 2, 2026, 16:56Mohammed Nasur: 1 Small Simulation, A Bigger Purpose
-
Nov 2, 2026, 16:54Carlos Guerrero: Presenting Our Latest Research on AI and Embryo Assessment at ASRM 2026
-
Nov 2, 2026, 16:52Sarah Lewen: My 1st ASRM Is Officially Complete
-
Nov 2, 2026, 16:49Jemma Garratt: Taking on the Role of Kind IVF and Data Science Manager at London Women’s Clinic