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Impact of Oxygen Concentration on Human Blastocyst Development – RBMO
RBMO/LinkedIn
Jan 18, 2026, 05:28

Impact of Oxygen Concentration on Human Blastocyst Development – RBMO

Reproductive BioMedicine Online shared a post on LinkedIn:

“New Hot Topic paper, selected by our Editors Mina Alikani and Richard Anderson.

Effect of constant (5%) versus gradient (8% to 2%) oxygen concentration on human blastocyst development: a sibling oocyte study by Peter Slatinšek, Milan Reljič, and Borut Kovačič․

Our Editors say:

‘Is mimicking in vivo oxygen conditions a better approach to embryo culture in vitro? Not according to this carefully designed and executed study. Can the potential interaction between culture media and oxygen levels explain these results?’

This prospective sibling-split study of 658 cumulus-oocyte complexes from 44 ICSI cycles shows that gradually lowering oxygen from 8% to 2% during the second half of embryo culture resulted in delayed blastulation and fewer clinically used blastocysts when compared with culture under static 5% oxygen.

Our Hot Topic papers are made free to read. Read it in full from issue 52.1, now․”

Title: Effect of constant (5%) versus gradient (8%–2%) oxygen concentration on sibling human blastocyst development

Authors: Peter Slatinšek, Milan Reljič, and Borut Kovačič

Impact of Oxygen Concentration on Human Blastocyst Development – RBMO

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and Borut Kovačič Blastocyst development Fertility Fertility News Human Blastocyst Milan Reljič Mina Alikani oxygen concentration Peter Slatinšek RBMO Reproductive BioMedicine Online reproductive health Reproductive Medicine Richard Anderson
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