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Higher ANA Titers Linked to Increased Risks of Infertility and Miscarriage – Fertility Plus
Fertility Plus/LinkedIn
Nov 9, 2025, 05:30

Higher ANA Titers Linked to Increased Risks of Infertility and Miscarriage – Fertility Plus

Fertility Plus shared a post on LinkedIn:

“ANA in IVF

Recent research by Yoshihara et al. (2025) offers key insights into anti-nuclear antibodies (ANA) in reproductive health. They determined that low-titer ANA (≤1:160) does not significantly impact live birth rates, suggesting a threshold where these antibodies may become clinically relevant. Conversely, higher ANA titers have previously been linked to increased risks of infertility and miscarriage.

This study emphasizes the importance of monitoring ANA levels in pregnancy planning and highlights the need for further research into how these antibodies influence reproductive outcomes. Understanding these thresholds can empower couples during their fertility journeys.
Association between antinuclear antibodies and pregnancy prognosis in recurrent pregnancy loss patients Open Access
H Yoshihara, S Goto, Tamao Kitaori, M Sugiura-Ogasawara
Human Reproduction, Volume 40, Issue 2, February 2025, Pages 236–243.”

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