The 4 Main IVF Stimulation Protocols – Fertility Plus
Fertility Plus shared on LinkedIn:
”The four main IVF stimulation protocols – explained in a line each.
Every IVF cycle follows the same path: baseline assessment, ovarian stimulation, monitoring scans, a trigger injection, then egg collection 34–36 hours later. What changes between protocols is how we stop your body ovulating too early.
Long GnRH agonist (luteal) – you start a daily agonist on day 21 of the previous cycle, then begin stimulation once your body is fully quiet. It’s the most established route: strong, predictable control, though it’s a longer cycle and uses more medication.
Short GnRH agonist (flare-up) – the agonist starts on day 2 and stimulation on day 3, using your body’s own initial surge of FSH and LH to help recruit follicles. Often chosen for women who are older or who’ve had a lower response before.
Ultra-short flare plus antagonist – three days of agonist to spark that early flare, then an antagonist added around day 5–6 to keep the cycle steady. A useful option where response has been limited previously.
GnRH antagonist – you begin stimulation on day 1 and add the antagonist later, either on a fixed day or once your leading follicle reaches about 14mm. No long down-regulation phase, simpler timing, and helpful flexibility where reducing the risk of OHSS matters.
There’s no single best protocol – only the one that suits your body, your history and your goals. At Fertility Plus, the same consultant plans, adjusts and sees your cycle through from start to finish, so decisions are made by someone who knows your case properly.”
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