Matteo Molè: Collaborative Innovations in Embryo Implantation Research
Matteo Molè, Assistant Professor of Medicine at Stanford University School of Medicine, shared a post on LinkedIn about papers published in Cell:
“Opening the ‘Black Box’ of Human Implantation.
We are proud to share our latest research, published in Cell: ‘Modeling human embryo implantation in vitro’
For decades, the moment a human embryo attaches to the uterus has remained a ‘black box’ biologically critical but impossible to observe. By creating CREST (Cell-engineered Receptive Endometrial Scaffold Technology), we have successfully achieved human embryo implantation in vitro.
- The Time is Now: We have moved beyond observing embryos in a dish; we can now study the complex interface between the embryo and the mother.
- Improving IVF: Implantation failure is the primary barrier to pregnancy. By recapitulating this process, we hope to understand why it fails and significantly increase success rates for patients.
- Global Collaboration: This was a massive joint effort between The Babraham Institute, IVIRMA Global, and Stanford University.
We are also excited to be part of a landmark trio of papers moving this field forward today. Please see the related work by our colleagues.”
Title: Modeling human embryo implantation in vitro
Authors: Matteo A. Molè, Sarah Elderkin, Irene Zorzan, Christopher Penfold, Nicole Horsley, Alexandra Pokhilko, Max Polanek, Andrea Palomar, Molika Sinha, Yang Wang, Alicia Quiñonero, Charalampos Androulidakis, Richard Acton, Kathryn Balmanno, Anneliese Jarman, Jhanavi Srinivasan, Adam Bendall, Sara Morales-Álvarez, Roberto Yagüe-Serrano, Katie Heywood, Stephen Harbottle, Mina Vasilic, Suzanne Cawood, Srividya Seshadri, Paul Serhal, Lauren Weavers, Ippokratis Sarris, Anastasia Mania, Rachel Gibbons, Lucy Laurier, Immaculada Sánchez-Ribas, Amparo Mercader, Pilar Alamá, Anthony Hoa Bui, Graham J. Burton, Tereza Cindrova-Davies, Ridma C. Fernando, Afshan McCarthy, Lusine Aghajanova, Liesl Nel-Themaat, Ruth B. Lathi, Simon J. Cook, Kathy K. Niakan, Alexander R. Dunn, Francisco Domínguez, Peter J. Rugg-Gunn
Read the full article.
Title: 3D post-implantation co-culture of human embryo and endometrium
Authors: Jinzhu Song, Rusong Zhao, Yu Zhang, Minghui Lu, Peishu Liu, Tao Li, Cheng Li, Ruijie Yu, Xueyao Chen, Huajian Yang, Xinwen Zhang, Yining Su, Yanli Han, Duanchen Sun, Qingbin Zhou, Zhenzhen Hou, Weijing Liu, Xiaoyuan Gao, Wenrong Tao, Jingye Zhang, Han Zhao
Read the full article.
Title: A 3D in vitro model for studying human implantation and implantation failure
Authors: Qian Li, Yang Yuan, Wentao Zhao, Yuanjun Li, Juanzi Shi, Yu Xiu, Mi Han, Yan Han, Junmei Zhang, Shuhan Cheng, Xin Qi, Xizhuang Sun, Tan Jia, Jiaqi Xing, Siwei Deng, Xiaodi Yan, Seiya Oura, Hongfei Li, Ying Sun, Huiyao Yuan, Xiaohong Ma, Miaomiao Xin, Jianchao Zhao, Xili Zhu, Cong Wang, Qin Wang, Ge Lin, Xiaokui Yang, Yulei Wei, Jun Wu, Hongmei Wang, Leqian Yu
Read the full article.
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