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Mohammad Haddadi: New Insights on Chronic Histiocytic Intervillositis Outcomes
Mohammad Haddadi/LinkedIn
Dec 31, 2025, 14:12

Mohammad Haddadi: New Insights on Chronic Histiocytic Intervillositis Outcomes

Mohammad Haddadi, Medical Doctor at Aflatoon Clinic, shared a post on LinkedIn about a paper published in International Journal of Gynecological Pathology:

“Proud to share our latest publication in the International Journal of Gynecological Pathology, ‘Placental Chronic Histiocytic Intervillositis: Pregnancy Outcomes and Complications – A Systematic Review and Meta-Analysis’.

Chronic histiocytic intervillositis (CHI) is a rare but serious placental inflammatory condition with profound implications for pregnancy outcomes. In this systematic review and meta-analysis, we synthesized evidence from 12 studies encompassing 568 pregnancies to better quantify maternal and neonatal risks associated with idiopathic CHI.

Key findings:

  • 40% pooled frequency of intrauterine growth restriction (IUGR)
  • 55% live birth rate
  • 20% intrauterine fetal death (IUFD)
  • Findings remained consistent in sensitivity analyses restricted to low-risk studies

Our results highlight the substantial burden of adverse outcomes associated with CHI and reinforce the need for early recognition, standardized diagnostic criteria, and targeted management strategies in affected pregnancies.

Grateful to work with an excellent team of collaborators. Looking forward to seeing how these findings contribute to improved placental pathology awareness and maternal–fetal care.

Link.”

Title: Placental Chronic Histiocytic Intervillositis: Pregnancy Outcomes and Complications, a Systematic Review and Meta-Analysis

Authors: Elena Ghotbi, Zeinab Mansouri, Alireza Azarboo, Nasim Eshraghi, Marjan Ghaemi, Mohammad Haddadi, Zahra Panahi, Sedigheh Hantoushzade

Mohammad Haddadi

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Alireza Azarboo Christine De Beer chronic histiocytic intervillositis Clinical Implications Elena Ghotbi Evidence Synthesis Fertility Fertility News Gynecological Pathology Intrauterine Risks Marjan Ghaemi maternal health Maternal Risks meta-analysis Nasim Eshraghi Neonatal Risks Placental Inflammation Pregnancy Complications Pregnancy Outcomes Pregnancy Research Rare Conditions Sedigheh Hantoushzade Systematic Review Zahra Panahi Zeinab Mansouri
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