Nichole Haeg: Exploring GLP-1s’ Hidden Impact on Fertility
Nichole Haeg, Account Manager and Pharmacy Practice Specialist at American Health and Wellness, shared a post on LinkedIn about a paper by Alberto Sola-Leyva et al. published in Acta Obstet Gynecol Scand and about a paper by Marie Couldwell et al. published in J Clin Endocrinol Metab:
“GLP-1s and Fertility – A secret key and a needed counseling point!
Here are my key take ways to consider:
- Currently, GLP-1s are not FDA approved for use in enhancing fertility, but research is ongoing.
- These medications show promise in improving fertility, especially in individuals with conditions like PCOS or obesity.
- The enhancement of fertility is attributed to factors such as weight reduction, improved insulin sensitivity, and the restoration of endocrine balance and endometrial receptivity.
- It is recommended to discontinue the use of GLP-1s four weeks before attempting conception and to avoid their use once pregnancy is confirmed.
- Ongoing research is crucial to gather more data on the effects of GLP-1s on fertility.
- For female patients not planning pregnancy, it’s important to educate them about the potential ‘side effect’ of increased fertility.
- I am interested to see more research regarding this relationship between GLP-1s and fertility.
Tavares ACM, Martins MYM, de Souza GF, Lima EM, Rocha CA, de Souza LC, Simões JML, de Araújo NO, Cavalcante MB. Immunological effects of GLP-1 analogs on female reproduction: Therapeutic perspectives for infertility and recurrent pregnancy loss. J Reprod Immunol. 2025 Jun;169:104538. doi: 10.1016/j.jri.2025.104538. Epub 2025 May 8. PMID: 40359784.
Couldwell M, Tidwell AJ, Taylor AE. Impact of GLP1 agonists on reproduction. J Clin Endocrinol Metab. 2025 Jul 14:dgaf401. doi: 10.1210/clinem/dgaf401. Epub ahead of print. PMID: 40658801.
Sola-Leyva A, Pathare ADS, Apostolov A, Aleksejeva E, Kask K, Tammiste T, Ruiz-Durán S, Risal S, Acharya G, Salumets A. The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation. Acta Obstet Gynecol Scand. 2025 Feb;104(2):258-266. doi: 10.1111/aogs.15010. Epub 2024 Dec 18. PMID: 39696822; PMCID: PMC11782050.”
Title: Effect of GLP1 Agonists on Reproduction
Authors: Marie Couldwell, Anna Jane Tidwell, Ann E Taylor
Read the full article:
Title: The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation
Authors: Alberto Sola-Leyva, Amruta D. S. Pathare, Apostol Apostolov, Elina Aleksejeva, Keiu Kask, Triin Tammiste, Susana Ruiz-Durán, Sanjiv Risal, Ganesh Acharya, Andres Salumets
Read the full article.
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