Fahimeh Ramezani Tehrani: New Findings on Oxidative Stress and PCOS Treatment
Fahimeh Ramezani Tehrani, Professor at Shahid Beheshti University of Medical Sciences, shared a post on LinkedIn about a paper published in Scientific Reports:
“Excited to Share Our Latest Research!
I am pleased to announce that our new article has been published in Scientific Reports:
‘Therapeutic efficacy of Rosa damascena Mill. on oxidative stress parameters and cyclooxygenase-2 gene expression in estradiol valerate-induced polycystic ovarian syndrome in Wistar rats’
DOI: 10.1038/s41598-025-17484-2
What we explored:
- Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age.
- Oxidative stress plays a key role in its pathogenesis.
- We investigated the therapeutic potential of Rosa damascena extract in a rat model of PCOS.
Key findings:
- Higher doses of Rosa damascena extract (800 and 1200 mg/kg/day) significantly improved oxidative stress markers.
- Reactive oxygen species (ROS) levels decreased.
- Cyclooxygenase-2 (Cox2) gene expression was notably reduced.
- The effects were comparable to metformin, a standard treatment.
Why it matters:
Our results highlight the potential of Rosa damascena as a natural therapeutic agent for alleviating PCOS complications, partly through regulating oxidative stress pathways.
I am grateful to my co-authors and collaborators for their contributions to this work. Looking forward to further discussions and future research in this area.”
Title: Therapeutic efficacy of Rosa damascena Mill. on oxidative stress parameters and cyclooxygenase-2 gene expression in estradiol valerate-induced polycystic ovarian syndrome in Wistar rats
Authors: Mahbanoo Farhadi-Azar, Fatemeh Mahboobifard, Maryam Mousavi, Marzieh Saei Ghare Naz, Maryam Farahmand, Parichehreh Yaghmaei, Fahimeh Ramezani Tehrani
Read the full article.
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