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Fahimeh Ramezani Tehrani: New Findings on Oxidative Stress and PCOS Treatment
Fahimeh Ramezani Tehrani/LinkedIn
Dec 30, 2025, 07:54

Fahimeh Ramezani Tehrani: New Findings on Oxidative Stress and PCOS Treatment

Fahimeh Ramezani Tehrani, Professor at Shahid Beheshti University of Medical Sciences, shared a post on LinkedIn about a paper published in Scientific Reports:

“Excited to Share Our Latest Research!

I am pleased to announce that our new article has been published in Scientific Reports:

‘Therapeutic efficacy of Rosa damascena Mill. on oxidative stress parameters and cyclooxygenase-2 gene expression in estradiol valerate-induced polycystic ovarian syndrome in Wistar rats’

DOI: 10.1038/s41598-025-17484-2

What we explored:

  • Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age.
  • Oxidative stress plays a key role in its pathogenesis.
  • We investigated the therapeutic potential of Rosa damascena extract in a rat model of PCOS.

Key findings:

  • Higher doses of Rosa damascena extract (800 and 1200 mg/kg/day) significantly improved oxidative stress markers.
  • Reactive oxygen species (ROS) levels decreased.
  • Cyclooxygenase-2 (Cox2) gene expression was notably reduced.
  • The effects were comparable to metformin, a standard treatment.

Why it matters:

Our results highlight the potential of Rosa damascena as a natural therapeutic agent for alleviating PCOS complications, partly through regulating oxidative stress pathways.

I am grateful to my co-authors and collaborators for their contributions to this work. Looking forward to further discussions and future research in this area.”

Title: Therapeutic efficacy of Rosa damascena Mill. on oxidative stress parameters and cyclooxygenase-2 gene expression in estradiol valerate-induced polycystic ovarian syndrome in Wistar rats

Authors: Mahbanoo Farhadi-Azar, Fatemeh Mahboobifard, Maryam Mousavi, Marzieh Saei Ghare Naz, Maryam Farahmand, Parichehreh Yaghmaei, Fahimeh Ramezani Tehrani

Read the full article.

Fahimeh Ramezani Tehrani

Stay updated on all scientific advances in the field of fertility with Fertility News.

Cyclooxygenase-2 Endocrine Disorders Fahimeh Ramezani Tehrani Fatemeh Mahboobifard Fertility Fertility News gene expression Hormonal Imbalance Mahbanoo Farhadi-Azar Maryam Farahmand Maryam Mousavi Marzieh Saei Ghare Naz oxidative stress Parichehreh Yaghmaei PCOS Polycystic Ovary Syndrome reproductive health Rosa Damascena
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