New Insights on HLA-G in Preeclampsia Revealed – Benthic Genomics
Benthic Genomics shared a post on LinkedIn about a paper by Satu Wedenoja et al. published in EBioMedicine:
“Fetal HLA-G: The master regulator of pregnancy success that affects even the sex of your baby.
A study of 1.79 million births by Satu Wedenoja et al. reveals that fetal HLA-G isn’t just about immune tolerance – it may actually influence whether pregnancies result in boys or girls.
Key findings from this landmark research:
- Male fetuses are underrepresented in preeclamptic births, especially those delivered preterm
- HLA-G expression is significantly downregulated in preeclamptic placentas
- Specific HLA-G genetic variants are associated with both pregnancy complications and offspring sex ratios
- Balancing selection at the HLA-G locus promotes genetic diversity as an evolutionary trade-off
HLA-G creates immune tolerance at the maternal-fetal interface, preventing the mother’s immune system from rejecting the fetus. When this system fails, it can lead to:
- Increased risk of preeclampsia
- Higher rates of stillbirth
- Altered sex ratios in affected pregnancies
The study found that placental HLA-G and IFNA1 expression distinguished preeclamptic pregnancies better than current biomarkers (FLT1 and PlGF), suggesting new diagnostic possibilities.
This research demonstrates how evolution has shaped pregnancy success through immune regulation, with HLA-G heterozygosity providing advantages for fetal survival.
Link to the full paper.
What role might HLA-G testing play in future prenatal care?”
Title: Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia
Authors: Satu Wedenoja, Masahito Yoshihara, Hindrek Teder, Hannu Sariola, Mika Gissler, Shintaro Katayama, Juho Wedenoja, Inka M. Häkkinen, Sini Ezer, Nina Linder, Johan Lundin, Tiina Skoog, Ellika Sahlin, Erik Iwarsson, Karin Pettersson, Eero Kajantie, Mikael Mokkonen, Seppo Heinonen, Hannele Laivuori, Kaarel Krjutškov, Juha Kere
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Oct 11, 2025, 06:44The Global IVF Market Is Set to Reach $65B by 2032 – Meddilink
-
Jan 28, 2026, 16:59Unlocking the Potential of Menstrual Blood in Health Testing – Global Women’s Health Innovation Conclave
-
Jan 28, 2026, 16:57New Insights on Oocyte Yield in Endometriosis and PCOM – RBMO
-
Jan 28, 2026, 16:51Transform Your Expertise with ESHRE eCampus Learning – ESHRE
-
Jan 28, 2026, 16:46Accelerate Your Growth at the AP3G National Meeting – ASRM
-
Jan 28, 2026, 16:43Debojit Saha: Unraveling Chromosomal Errors in Aging Human Eggs
-
Jan 28, 2026, 16:38Silvia Vannuccini: RBMO Highlights Key Insights on Adenomyosis Awareness
-
Jan 28, 2026, 16:32Maximilian Attwood: Challenging Medical Misogyny in Endometriosis Research
-
Jan 28, 2026, 16:29Ioakeim Sapantzoglou: New Perspectives on Fetal Growth Restriction and Genetic Testing
-
Jan 28, 2026, 16:26Enhancing Pre-Eclampsia Prediction with Doppler Indices – ISUOG